Caracterização da resposta imune humoral em trabalhadores da área da saúde frente a antígenos recombinantes de Mycobacterium tuberculosis
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Data
2007-12-12
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Universidade Federal de Goiás
Resumo
Tuberculosis (TB), one of the oldest disease in the world, is until our days a
public health concern. It s believed that one third of the world s population is
latently infected. Brazil is an endemic area for TB and its incidence in 2005
was about 60 cases per 100.000 inhabitants. One of the most important
challenge in TB control is the identification of individuals who are latent
infected. Health Care Workers (HCW) are at high risk of getting infected with
Mycobacterium tuberculosis and because of that they had increased
chances to became ill. The aim of this work was to elucidate the sorological
profile of latent infected HCW through the antibody response against proteic
recombinant antigens from Mycobacterium tuberculosis, GLcB, Hspx and
MPT51. It was observed that almost 70% of HCW presented antibodies (IgM
and IgG) against these antigens. When IgM was measured, the negative
TST HCW showed higher antibodies s levels than the positive TST HCW.
When IgG was measured, negative and positive TST HCW showed similar
antibodies´s levels. Men and women also showed similar antibodies´s levels
against those antigens. The antibodies s levels were also similar between BCG-vaccinated and BCG non-vaccinated HCW, the same occurs among
the different professional categories. There isn t any relation between the
antibody responses (humoral response) and TST results (cellular response).
These results showed that the majority of the HCW presented antibodies
against the proteic recombinant antigens GLcB, Hspx e MPT51 of
Mycobacterium tuberculosis independent of the TST response.
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REIS, Michelle Cristina Guerreiro dos. Characterization of humoral immune response of health care workers against recombinant antigens from Mycobacterium tuberculosis. 2007. 66 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Goiás, Goiânia, 2007.