Avaliação pré clínica da toxicidade aguda e da atividade diurética oral do extrato aquoso bruto das folhas da palicourea coriacea (cham.) k. Schum (Rubiaceae) douradinha do campo
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Data
2011-08-29
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Universidade Federal de Goiás
Resumo
Palicourea coriacea (Cham.) K. Schum, known as douradinha or douradinha-docampo,
is a plant of Cerrado in the form of sub-shrubs with yellow flowers, belonging
to the Rubiaceae family. Its leaves are used in preparations of home remedies in the
form of teas, to treat kidney stones, inflammation / infection of the urethra, kidneys,
bladder, and as a diuretic. This study aimed to evaluate the acute toxicity in rats and
mice, as well as the diuretic activity in rats of the crude aqueous extract of dried
leaves Palicourea coriacea (EABLPC). The acute oral toxicity EABLPC was
investigated according to OECD 423. To evaluate the diuretic activity three groups of
rats received doses of EABLPC (80, 160 and 320 mg / kg), one group received only
saline solution, and another received furosemide (20 mg / kg) administered by
gavage for eight days, being made volume measurement and evaluation of urinary
concentrations of electrolytes (Na+, K+ and Cl-), creatinine and urea in urine and
blood. The extract did not develop signs of toxicity or mortality in animals and found
no pathological changes. In the evaluation of diuretic activity observed - an increase
in urinary volume, water consumption and excretion of electrolytes, mice treated with
EABLPC, compared to untreated, but not statistically significant differences were
detected in blood samples. The results showed that the extract belongs to Class 5
(Substances with LD50 greater than 2000 mg / kg), being considered of low toxicity.
The increase in urine volume, water consumption and excretion of electrolytes
confirmed the diuretic activity of EABLPC. This study confirmed the use of
ethnopharmacological EABLPC.
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PEREIRA, Marcelo Elias. Evaluation Pre - clinical and Acute toxicity
oral Diuretic activity of aqueous extract of Raw Leaves Palicourea coriacea (Cham.) k. Schum (Rubiaceae) douradinha do campo . 2011. 94 f. Dissertação (Mestrado em Ciências da Saúde - Farmácia) - Universidade Federal de Goiás, Goiânia, 2011.