AVALIAÇÃO DA TOXICIDADE ORAL AGUDA E DAS ATIVIDADES DIURÉTICA E ANTIOXIDANTE, DA Rudgea viburnoides (CHAM.) BENTH. (CONGONHA-DE-BUGRE)
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Data
2009-06-16
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Universidade Federal de Goiás
Resumo
The Rudgea viburnoides (Cham.) Benth. (Rubiaceae), popularly known as
"congonha, congonha-de-Bugre or Bugre" is used in folk medicine as diuretic,
hypotensive, anti-rheumatic and depurative of blood (leaves tea). This species is
being traded as "porangaba" and used in weight loss programs. This work aimed to
study the acute toxicity, the diuretic and antioxidant activities of R. viburnoides. The
test for acute toxicity in single dose was performed with the ethanolic crude extract,
administered orally, at concentrations of 2000mg/kg and 5000mg/kg in mice and rats
of both sexes by the testo of Class.To test for diuretic activity in rats, it was used the
crude ethanolic extract of the leaves at concentrations of 40mg/kg, 80mg/kg and
160mg/kg, and furosemide 20mg/kg as positive control. The determination of total
phenols of the crude extract and fractions (hexane, dichloromethane, ethyl acetate
and methanol/water) was performed by the method of Butler and Hargerman and
the evaluation of antioxidant activity performed by the method of 2,2-diphenyl-1-
picryl -hidrazil (DPPH). There was no acute toxicity of crude ethanolic extract of the
leaves and it was classified as non toxic.The results has shown that the ethanolic
extract presented dependent dose diuretic effect higher than furosemide, used as
positive control. The crude ethanolic extract showed 0.84% of total phenols, the
fraction hexanic 0.44%, the dichloromethane fraction 1.91%, the fraction of ethyl
acetate fraction 15.43% and the fraction methanol/water 7.92%. The ethyl acetate
fraction showed better antioxidant action. The results obtained so far may justify the
popular use of Rudgea viburnoides as diuretic
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Citação
PUCCI, Liuba Laxor. EVALUATION OF ORAL TOXICITY AND ACTIVITIES
DIURETICS AND ANTIOXIDANT, DA Rudgea viburnoides (Cham.)
BENTH.
(Congonha-DE-BUGRE). 2009. 87 f. Dissertação (Mestrado em Ciências da Saúde - Farmácia) - Universidade Federal de Goiás, Goiânia, 2009.