Colonização pelo streptococcus do grupo b: prevalência, fatores de risco, características fenotípicas e genotípicas, em mulheres no terceiro trimestre de gestação, atendidas por serviço de referência materno infantil de Goiânia-Goiás
Carregando...
Data
2009
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
To estimate the prevalence, to asses risk factors for Group B
Streptococcus (GBS) colonization and to describe phenotypic and genotypic
characteristics of isolated strains from pregnant women in Goiânia, Goiás. Methods:
A cross sectional study was carried out among 198 pregnant women, at least at the
32o weeks´ gestation, attending a reference health unit, from March to June 2009.
Socio, demographic and obstetric profiles were investigated using a standard
questionnaire. Samples of vaginal and rectal secretion were collected and placed into
selective enrichment broth Todd-Hewitt. Tests for GBS identification (gram, catalase
and CAMP) followed by susceptibility test using antibiotic disk diffusion technique
were performed. Genetic diversity was assessed by pulsed-field gel electrophoresis
(PFGE). Descriptive and analytic statistical tests were applied (Epi Info e SPSS
13.0). Analyses were performed at the Instituto de Patologia Tropical Saúde
Pública/UFG. Results: Thirty pregnant women were colonized by GBS yielding a
prevalence of 15.2% (IC95% 10.5 ?? 20.9). Pregnant women younger than 20 years
and with low income had higher risk of GBS colonization, in univariate analysis
(p<0.05). GBS was isolated from 28 vaginal and 14 rectal specimens. Twelve
pregnant were vaginal and rectal colonized. All 42 strains were susceptible to
penicillin, vancomycin, ceftriaxone and levofloxacin. Three strains (7.1%) were
resistant to erythromycin and two (4.7%) to clindamycin. 19 pulsotypes and four
clusters were identified. Nine out 12 pars of positive strains (vaginal and rectal) were
genetically identical, two were stricted related and one par was colonized by different
strains. The same genetic profile was observed in more than one pregnant.
Conclusions: Socioeconomic and obstetrics variables had low predictive value for
GBE colonization among pregnant women, reinforcing the need for universal
microbiology screening strategy in this population, in order to prevent neonatal
sepsis. A high genetic diversity of GBS was found among pregnant women in
Goiania.
Descrição
Palavras-chave
Citação
PIRES, Telma Sousa. Colonização pelo streptococcus do grupo b: prevalência, fatores de risco, características fenotípicas e genotípicas, em mulheres no terceiro trimestre de gestação, atendidas por serviço de referência materno infantil de Goiânia-Goiás. 2009. 81 f.Dissertação ( Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2009.