Efeito do nicotinato de cromo na sensibilidade à insulina e antropometria em indivíduos com diabetes mellitus tipo 2
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Data
2012-02-02
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Universidade Federal de Goiás
Resumo
Chromium dietary interventions have been used to investigate the improvement
in insulin sensitivity due to the role of chromium as a central component of the
glucose tolerance factor. This study aims investigate the effect of chromium
nicotinate supplementation on insulin sensitivity and anthropometry in type 2
diabetic subjects. In double-blind trial, fifty-six type 2 diabetic subjects with Body
Mass Index 25 kg/m2 and increased waist circumference were randomized
into three groups: placebo (NC0), 50μg (NC50) and 200μg (NC200) of chromium
nicotinate. Status of chromium, insulin resistance, cell function, glycemic
control, lipid profile, anthropometry, intensity and energy expenditure in physical
activity were assessed at the beginning, 45 and 90 days of intervention. Energy
consumption was assessed at the beginning, between the beginning and 45
days and between 45 and 90 days of study. Most subjects had low serum levels
of chromium (71.88%), normal levels of urinary chromium (80.65%) and insulin
resistance (73.80%). Chromium serum concentrations did not differ between
groups over time (p = 0.2549). Changes in concentrations of serum and urinary
chromium were not related to changes in fasting glucose (p> 0.05). At 90 days,
there was no significant intra-group difference in fasting plasma glucose,
glycosylated hemoglobin, HOMA-IR, total cholesterol, LDL cholesterol, waist
circumference, % body fat and % lean mass. There was an increase in HOMA-
(p = 0.0349) and HDL cholesterol (p = 0.0425) in the group NC0, reduction in
triglycerides in NC0 group (p = 0.0177) and NC50 (p = 0.0336) and reduced of
1.08 kg in the NC50 group (p = 0.0048). No difference was found at intra-group
physical activity intensity and between supplemented groups (NC50 and NC200)
and placebo (NC0) at 90 days (p>0.05). There was an increase in physical
activity energy expenditure in NC50 group at 90 days (p = 0.0371). As for total
energy intake, there was no difference within and between groups during the
study (p> 0.05). Supplementation with 50 μg and 200 μg chromium nicotinate for
90 days did not promote improvements in glucose homeostasis, lipid profile and
anthropometry in individuals with type 2 diabetes mellitus.
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GUIMARÃES, Marília Mendonça. Efeito do nicotinato de cromo na sensibilidade à insulina e antropometria em indivíduos com diabetes mellitus tipo 2. 2012. 130 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2012.