Desenvolvimento tecnológico de extratos vegetais padronizados a partir da Lafoensia pacari A. St.-Hill (Lythraceae)
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2013-02-28
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Universidade Federal de Goiás
Resumo
Lafoensia pacari A. St.-Hill (Lythraceae) popularly known as dedaleiro, didal,
or mad-mangabeira pacari, is used by the Brazilian population as a febrifuge, tonic
and healing. Studies have shown the antioxidant, anti-inflammatory, and
antinoceptiva antiedematogenic extracts from the stem bark, ellagic acid being one of
those responsible for the same. This study aimed to obtain dry extract standardized
technology from the stem bark of L. pacari. The drug was tested for various quality
control tests, according to the Brazilian Pharmacopoeia 5th edition, which ensured
the characterization of plant drug and subsequently obtaining the liquid and dry
extracts standardized. The extraction method was chosen slow percolation with 80%
hydroalcoholic solution as a solvent and velocity of 7 drops per min .. The liquid
extract standardized had a density of 0.986 g / mL solids content of 12.49% (w / w),
pH 3.53 and an alcohol content of 44.80% (v / v). The content of ellagic acid found in
liquid extract was 3.84% (m / m). The spray drying / atomization was performed by
experimental design of univariate and then by planning a fractional 5-2 with 2
replicates. During the process the adjuvants were used maltodextrin and aerosil,
demonstrating that the optimal conditions found maltodextrin provides greater
protection and ellagic acid concentration in the extract.
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CARDOSO, Natasha Queiroz. Desenvolvimento tecnológico de extratos vegetais padronizados a partir da Lafoensia pacari A. St.-Hill (Lythraceae). 2013.94 f. Dissertação (Mestrado em Ciências Farmacêuticas (FF) - Universidade Federal de Goiás, Goiãnia, 2013.