Sulfato de vincristina no tratamento do tumor venéreo transmissível frente à caracterização citomorfológica
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Data
2009-12-18
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Universidade Federal de Goiás
Resumo
The transmissible venereal tumor (TVT) is among the most common cancers in
dogs in Brazil. This is a sexually transmitted cancer through a mechanism of
transplantation of viable tumor cells, it has high incidence among dogs of both
sexes in reproductive age, with high occurrence in areas of high concentration of
dogs with poor control of reproduction. The diagnosis made in the routine of
clinical medicine is usually based only on clinical symptoms and the chemotherapy
of choice has been the vincristine sulfate. This drug has been shown in most
cases a good response to treatment with complete regression of the tumor, but
there are also cases where the tumor appears resistant to treatment. This study
aimed to demonstrate the practicality of using fine needle aspiration cytology as a
method of diagnosis and cytomorphologic classification, being effective and safe
as well as measuring the response of different cytomorphologic groups forward to
treatment with vincristine sulfate. Also evaluating the clinical response,
hematologic and biochemical tests using serum liver function (ALT) and renal
(creatinine), in the therapy instituted. Were evaluated and treated 18 dogs of both
sexes, carrying TVT, which received six consecutive weeks during the
administration of vincristine sulfate in the dosage of 0.03 mg / kg administered
intravenously. The animals underwent weekly prior to medication, clinical
assessment, haematological and biochemical. It was observed in this study that
cytological examination is a simple technique, minimally invasive and painless,
and a safe method that provides no risk to the patient's life and does not require
the use of sophisticated equipment, sedation or anesthesia for their achievement.
Animals carrying the TVT plasmacytoid type, had higher rate of tumor resistance
to treatment in relation to established groups and linfocytic mixed, showing a
greater resistance to treatment with this group of vincristine sulfate. The efficiency
of response to treatment was presented by the linfocytic group. The vincristine
sulfate showed few side effects, low hematological, hepatic and renal toxicity, it is
therefore an effective option in the control of transmissible venereal tumor in not
resistant cases.
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Citação
SIMERMANN, Nívia Faria Silva. Vincristine sulfate in the treatment of tumor
venereal front of the characterization
cytomorphological. 2009. 64 f. Dissertação (Mestrado em Ciências Agrárias - Veterinaria) - Universidade Federal de Goiás, Goiânia, 2009.