Correlação entre espessura médio-intimal carotídea e medidas centrais da pressão arterial obtidas por tonometria e oscilometria. Uma prova de conceito
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2019-03-14
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Universidade Federal de Goiás
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Background: Early detection of vascular damage in subclinical stages of hypertensive desease may be the key to optimizing the prevention of cardiovascular outcomes. Objectives: To correlate structural vascular damage parameters by measuring carotid intima-media thickness (IMT) with functional vascular damage parameters through central hemodynamic measurements in prehypertensive and hypertensive patients using up to two hypertensive drug classes. Method: A descriptive cross-sectional study was performed on a convenience sample of patients from the League of Arterial Hypertension (LHA∕UFG). Patients with arrhythmia, previous cardiovascular and cerebrovascular deseases, as well diabetes and end stage deseases were excluded. Were performed carotid doppler, peripheral and central blood pressure measurements by applantion tonometry (Sphygmocor®) and oscillometry (Mobil O´Graph®). Comparisons and correlations were performed using the t-test and Pearson´s test, respectively, considering as significant p<0,05. Results: Twenty participants were evaluated, predominantly female (60%), with a mean age of 53.8 ± 14.3 years. The measurements made by the different methods were similar except for the central pulse pressure (PPc) (42,9 ± 13,9 mmHg X 34,7 ± 9,6 mmHg, p=0,01) and pulse wave velocity (PWV) (9,0 ±1,9 m∕s X 7,9 ± 1,5 m∕s, p=0,01), with higher values obtained by applanation tonometry. It was established correlation between IMT and PWV obtained exclusively by the oscillometric method (r=0,659; p=0,002). No correlation was established between central hemodynamic variables and carotid artery plaques. Conclusion: The only central hemodynamic parameter that correlated with IMT was the PWV obtained by oscillometric method.
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MELO, Milena de Andrade. Correlação entre espessura médio-intimal carotídea e medidas centrais da pressão arterial obtidas por tonometria e oscilometria. Uma prova de conceito. 2019. 54 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2019.