Avaliação do processo eletroquímico na degradação de amoxicilina e determinação de toxicidade dos subprodutos gerados
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2019-03-22
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Universidade Federal de Goiás
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Introduction: Amoxicillin (AMX) is one of the world's most widely prescribed antibiotics for the treatment and prophylaxis of bacterial infections, in both human and veterinary medicine. The incomplete removal of this drug during the treatment of wastewater has attracted the attention of several researchers due to the risks of its bioaccumulation and consequent bacterial resistance. The electroemediation of drugs is of great value in the environmental scope, since electrochemical methods have several advantages when compared to the tools commonly used in the treatment of pharmaceutical and urban effluents. Objective: To evaluate the efficiency of the electrochemical process in the degradation of AMX using different electrolytic media and electrodes, as well as to investigate the adverse effects of the antibiotic before and after the electrochemical remediation. Methodology: The electrochemical tests were performed in three electrolytic media (tap water, Na2SO4 or NaCl solutions) and three anodes (carbon [C], titanium [Ti] and carbon modified with titanium oxide [TiO2 @ C]). The samples analyzed before and after the electro-oxidation were monitored by UV-visible, mass spectrometry and differential pulse voltammetry. After the electrooxidation process, the treated AMX solutions were analyzed by the ecotoxicity test with Danio rerio (zebrafish; paulistinha) and the minimum inhibitory concentration was calculated to determine the antimicrobial potential after treatment. Results and discussion: The titanium oxide modified carbon anode [TiO2 - C]) showed high efficiency, leading to the complete removal of amoxicillin in less than 10 minutes, in the order: [TiO2 @ C]> [Ti]> [C]. The dose of the electrolytes is supported in the following order: 0.1 M NaCl> Na 2 SO 4> 0.01 M NaCl> tap water. Amoxicillin does not pulse cardiac impressive of zebrafish during long term exposure. Conclusions: The electrooxidation of amoxicillin using TiO2 electrode in 0.01 M NaCl solution was able to decrease the antimicrobial activity of amoxicillin. At a high concentration of electrolyte, there is an increase in the rate of drug removal, there is why it is not the habitat that the zebrafish has become a toxic environment. The technique has been serous in the degradation of amoxicillin and can be applied to other organic pollutants.
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CAETANO, M. P. Avaliação do processo eletroquímico na degradação de amoxicilina e determinação de toxicidade dos subprodutos gerados. 2019. 67 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2019.