Crisina previne a neurotoxicidade induzida por cloreto de alumínio em camundongos swiss machos
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2022-01-28
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Universidade Federal de Goiás
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Chronic aluminium (Al) metal accumulation contributes to the progression of several
neurological and neurodegenerative diseases. In particular, Al promotes oxidative damage,
neuronal death, and functional decline resulting in deficits in cognition, memory and behavior.
In this regard, the use of natural antioxidants can be a strategy to prevent the neurotoxicity of
Al. Chrysin is a natural phenolic compound found in foods such as honey, passion fruit, and
propolis and with antioxidant and anti-inflammatory properties. Here, we evaluated the chrysin
neuroprotective effects against the neurotoxicity induced by chronic exposure to aluminium
chloride (AlCl3), in mice (100 mg/kg, p.o.). The experimental protocol consisted of the
treatment of mice with AlCl3 for ninety consecutive days, being the chrysin administration (10,
30. 100 mg/kg, p.o.) started on the forty-sixth day of the Al intake. Chrysin reduced the
cognitive impairment induced by AlCl3 in the step-down passive avoidance task, normalizing
the hippocampus acetylcholinesterase and butyrylcholinesterase activities. Along with this,
chrysin decreased oxidative damage observed in the parameters of the lipid peroxidation,
protein carbonylation, catalase and superoxide dismutase activities in the brain cortex and
hippocampus. Furthermore, necrotic cells frequency was also decreased by chrysin in the same
brain regions. These results highlighted that chrysin is able to reduce the neurotoxic effects
associated with Al chronic exposure, being a potential compound present in foods that can be
used for the benefit of mental health.
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CAMPOS, H. M. Crisina previne a neurotoxicidade induzida por cloreto de alumínio em camundongos swiss machos. 2022. 95 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2022.