Desenvolvimento de carreador lipídico nanoestruturado contendo filtro UV avobenzona
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2022-09-30
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Universidade Federal de Goiás
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Introduction: Avobenzone (AVB) is an organic filter, acting in the ultraviolet (UV) A spectrum. It is
a cosmetic ingredient that presents photo-instability, impairing its photoprotective activity. For AVB
photoprotection, its molecule must be in conformation, however, exposed to a UV photoisomerization
it undergoes, passing to a keto form, which has no protection against UVA radiation. Objective: To
develop and characterize a nanostructured lipid carrier (NCL) containing AVB and to evaluate its
photostability. Methods: The High Performance Liquid Chromatography (HPLC) method was
validated to evaluate the AVB. The AVB compatibility with the selected components was the premeans
evaluation of thermal analysis of spectrogravimetry and Fourier transformed infrared (FT-IR)
porscopy. AVB solubility was for 24 hours by temperature test, under temperature of 37°C, for 24
hours. Afterwards, the components for the composition of the recommended formulation were
selected as reasons according to the literature. For the maintenance of the CLN, the method of
inversion of phases with application of microfluidization was used. To characterize the performance
of the tests: preliminary stability for 14 days, average stability and follow-up of the formulation,
evaluation of polydispersity, 30 days, evaluation of pH parameters, particle size, index index (Pd)
and content. The encapsulation efficiency (EE%) was performed by the indirect method. The photo
stable study lasted 24 hours and consisted of the evaluation of the NLC containing AVB under UVA
radiation. The surface of the nanoencapsulated skin surface, AV was projected for 24 hours, using
the Franz interface. Results and discussions: the studies of definition of average size, corroborate
for the definition of the components of the CLN, isopropyl myristate, 80 and span 85. After the
conclusion of the white CLN, the results of size and PdI of 145.9 ± 57 were obtained. .32 nm and
0.196 ± 0.04, respectively. When an AVB was incorporated into the CLN, 135.77 ± 7.27 nm of mean
size and 0.150 ± 0.09 of PdI were obtained. For EE%, the value of 72.82± 1.81% of asset
encapsulation was generated. Subsequently, the capacity test was performed, to which the
solubilized AVB test was presented and the solubilized AVB presentation of solubilized AVB was
presented and tested in how much AVB sampled the sample not presented to exposure. The AVB,
did not show permeation of clothes in the skin CLN, having its actions in the skin of the CLN, having
its skin. Conclusion: Thermal studies will allow the proper selection of formulation constituents. The
functional treatment system developed, with protected CLN photo treatment features, and CLN photo
treatment features protective conditions, thus, face to face UV. As for its safety, it is seen that the
AVB remained mostly retained in the stratum corneum, it did not present permeation to the skin.
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SOUSA, I. P. Desenvolvimento de carreador lipídico nanoestruturado contendo filtro UV avobenzona . 2022. 85 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2022.