Ki-67, cd10, cd34, p53, cd117 e mastócitos no diagnóstico diferencial dos fibroadenomas celulares e na graduação dos tumores filóidesz
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2013-10-09
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Universidade Federal de Goiás
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The proper management of breast phyllodes tumors (PTs) remains challenging, due to the difficulty of the correct preoperative diagnosis. The aim of this study was to evaluate the usefulness of the Ki-67, CD10, CD34, p53, CD117 and the number of mast cells for the differential diagnosis between benign PTs and cellular fibroadenomas (CFs), and also at the
grading of PTs. 51 primary PTs and 14 FCs were examined by immunohistochemistry (IH). Through the evaluation of the expression of CD117, greater epithelial expression was found at the FCs and an increased number of mast cells in benign TFs. The stromal expression of the Ki-67, CD10, CD34 and p53 showed relevance to the grading of PTs.
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VILELA, Maria Helena Tavares. Ki-67, cd10, cd34, p53, cd117 e mastócitos no diagnóstico diferencial dos fibroadenomas celulares e na graduação dos tumores filóides. 2013. 45 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2013.