Risco cardiovascular em mulheres com câncer de mama
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Data
2013-12-12
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Universidade Federal de Goiás
Resumo
OBJECTIVES: To investigate the prevalence of risk factors for cardiovascular
disease (CVD), estimate the cardiovascular risk, acoording to the
Framingham and Systematic Coronary Risk Evaluation (SCORE) risk
models, and evaluate the agreement between both risk models in middleaged
breast cancer survivors (BCS).
METHODS: A cross-sectional study was conducted between august 2002
and june 2003, including 67 breast cancer survivors. Participants were
recruited from the Menopause and Breast Cancer Outpatient Facilities (
Universidade Estadual de Campinas - UNICAMP), ranging in age from 45 –
65 years, who underwent complete oncologic treatment and were not users
of hormone replacement therapy, tamoxifen or aromatase inhibitors in the
last six months. Evaluated risk factors for CVD like us: dyslipidemia, obesity,
arterial hypertension, diabetes and smoking, and risk of CVD. The risk of
CVD was estimated according to the Framingham and SCORE models. The
risk of CVD was classified as low ( < 10%) , moderate ( 10 -20%) and high (
> 20%), according to Framingham function, and low ( < 3%), moderate ( ≥
3% and < 5%) and high ( ≥ 5%), according to SCORE model. A descriptive
analysis with absolute and relative frequencies, means and standard
deviations (SD) was carried out. To investigate agreement between both risk
models, the kappa coefficient was calculated with is respective 95%
confidence interval (CI).
RESULTS: The mean age of the participants was 53.2± 6.0 years and body
mass index (BMI) was 27.8 ± 5.7 Kg/m². Obesity and arterial hypertension occurred in 27% and 34% of participants, respectively. Ninety percent of
participants had at least one type of dyslipidemia. The most prevalent
dyslipidemias were: high total cholesterol levels (≥ 200 mg/dl) in 70%, high
LDL-C (≥ 130 mg/dl) in 51% and high non-HDL-C (≥ 160 mg/dl) in 48% of the
participants. The risk of CVD, according to the Framingham model, was
classified as low (45%), moderate (33%) and high (22%); and low (96%) and
moderate (4%) according to the SCORE equation. The agreement between
Framingham and SCORE models was poor (kappa coefficient of 0.122 with
95% CI: 0.013 to 0.231).
CONCLUSIONS: The prevalence of risk factors for cardiovascular disease
was high. Dyslipidemia was common in this cohort. The majority of
participants had low to moderate cardiovascular risk. The agreement
between both risk models was poor. These data indicate that the prevention
of CVD in middle-aged breast cancer survivors is necessary and close
attention should be focused on adequate control of serum lipid levels.
KEYWORDS: breast cancer, dyslipidemia, disease cardiovascular, score of
cardiovascular risk.
Descrição
Citação
SILVA, Érika Pereira de Sousa e. Risco cardiovascular em mulheres com câncer de mama. 2013. 113 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2013.