Estudo da resposta sistêmica aguda, da formação de aderências peritoniais e da produção de colágeno ao implante do compósito tela de polipropileno-filme à base de quitosana em suínos
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Data
2013-08-16
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Universidade Federal de Goiás
Resumo
Abdominal wall defects may require anatomical and functional reconstruction, what is usually achieved with the use of meshes. However these materials can trigger the formation of adhesions. To minimize or abolish this process one side of the mesh can be coated with a product that stands between this material and the visceral peritoneum forming a composite. The present study evaluated the systemic and tissue response to the implantation of composite polypropylene mesh-based film of chitosan 2QM (PQ group), compared to promoted by polypropylene mesh alone (group PP), intraperitoneally implanted in the abdominal cavity of pigs. After 28 days evaluation was performed by ultrasonography and video-laparoscopy. No significant difference was observed between the two groups of animals with respect to the formation of adhesions (P> 0.05). Systemic reactions were evaluated by means of the leukocyte count, C-reactive protein dosage, seric total protein, albumin and globulins which also showed no significant difference between groups (P1> 0.05). The systemic response was proportional to the composite response promoted by polypropylene mesh. However, the tissue inflammatory response was higher in the PP group (P = 0.0033). The number of polymorphonuclear cells increased statistically in the region of the implant in PQ group (P = 0.0068). Type I collagen and total collagen predominated in the implant regions in PP group (P = 0.0154 and P = 0.0037 respectively). It was concluded that the composite polypropylene mesh-chitosan based film has not promoted systemic response in animals, but the tissue inflammatory response was represented by a slow influx of polimornucleares. It can be inferred that the thickness of the chitosan based film was a factor that hindered the incorporation the composite by tissue receptor along with the slow degradation of the polysaccharide in vivo.
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Palavras-chave
Laparoscopia , Quitosana , Peritônio , Colágeno , Ultrassonografia , Laparoscopy , Chitosan , Peritoneum , Collagen , Ultrasonography
Citação
MARTINS, Apostolo Ferreira. Estudo da resposta sistêmica aguda, da formação de aderências peritoniais e da produção de colágeno ao implante do compósito tela de polipropileno-filme à base de quitosana em suínos. 2013. 79 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2014.