Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada
Carregando...
Data
2012-05-28
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
OBJECTIVE: To describe tuberculosis treatment rates of cure, failure and default of
a self administered regimen, with rifampin, isoniazid, pyrazinamide and ethambutol
in the first two months of treatment followed by isoniazid and rifampcina in the four
last months (2RHZE/4RH) in four-drug fixed-dose combination (FDC), implemented
in Brazil since 2010 to replace a regimen of separately administered rifampicin,
isoniazid and pyrazinamide in the first two months of treatment followed by
isoniazid and rifampcina for four months (2RHZ/4RH). METHODS: Descriptive
study using prospectively collected data from medical records of TB cases, older
than18 years of age undergoing treatment with 2RHZE/4RH in two units of primary
health care in the metropolitan area of Goiânia. RESULTS: The study included 40
cases of TB. The cure rate was 67.5% (27/40), the abandonment was 17.5% (7/40)
and there were no cases of failure. There was reports of adverse reactions in 47%
(19/40) of the cases. Of these, 87% were mild and 13% were moderate. There was no
need for change or suspension of the scheme. CONCLUSIONS: The cure rate in
FDC 4RHZE/2RH scheme under self-administered regimen was similar to historical
rates of cure with 2RHZ/4RH. The default rate in the sample studied was much
higher than the rate recommended as appropriate (up to 5%).
Descrição
Palavras-chave
Citação
FERREIRA, A. C. G. Desfechos clínicos do tratamento de tuberculose utilizando esquema RHZE em comprimidos com dose fixa combinada. 2012. 72 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2012.