Contagem automática tridimensional dos folículos ovarianos durante o ciclo menstrual
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Data
2015-01-31
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Universidade Federal de Goiás
Resumo
OBJECTIVES: To evaluate the variability of three-dimensional automatic counting of
follicles measuring between 2 - 6 mm and 2 - 10 mm during the menstrual cycle.
Considering that this is a standard exam for the early follicular phase, to check if this
test can be applied during other phases of the ovarian cycle. METHODS: A
Prospective observational study. Serial transvaginal ultrasound scans were
performed from 04/20/2013 to 10/30/2014 on infertile patients. Inclusion criteria
included age between 18 and 35 years, body mass index 18-25 kg / m2, regular
menstrual cycles, no history of ovarian surgery and no hormonal changes to TSH,
prolactin, fasting insulin and fasting glucose. Those patients with ovarian cysts or
who did not complete one or more days of the serial transvaginal ultrasound scans
and who did not undergo three-dimensional (3D) scanning with the researcher, were
excluded. The antral follicle count was taken in 3D mode with automated software.
Visits were scheduled for early follicular (2 to 5 days), mid-follicular (days 6 - 10),
periovulatory (days 12 - 16) and luteal (days 20 - 26) phases of the menstrual cycle.
RESULTS: Forty-five women were included. The Friedman test showed that the total
number of antral follicles measuring 2-6 mm varied significantly (p=0.001) across the
four periods of the menstrual cycle. The Paired Student’s t-test showed a significant
increase in follicles count 2-6 mm from the mid-follicular and periovulatory to the
luteal phase. We found no significant intracycle variation between the small antral
follicles (2-6 mm) in the early follicular, mid-follicular and periovulatory phases. The
Friedman test showed that the total number of antral follicles measuring 2-10 mm
varied significantly (p=0.003) across the menstrual cycle. Paired Student’s t-test
showed a significant increase in count from the early follicular to the mid-follicular
phase. CONCLUSIONS: The variation of three-dimensional automatic follicles
counting 2-6 mm in the early follicular, mid-follicular and periovulatory phases was
not statistically significant. There was a significant variation in the 3D automatic count
of ovarian follicles measuring 2-10 mm during the menstrual cycle. The significant
variability in the counting of antral follicles measuring 2-10 mm across the menstrual
cycle does not permit this examination to be carried out of early follicular phase.
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CASTRO, E. C. de. Contagem automática tridimensional dos folículos ovarianos durante o ciclo menstrual. 2015. 109 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.