Estudo comparativo entre duas insulinas humanas recombinantes NPH no tratamento do diabetes mellitus tipo 2
Carregando...
Data
2014-09-13
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Background: The number of patients with Type 2 Diabetes Mellitus (T2DM) in Brazil
has, in recent decades, increased substantially and insulin therapy is often necessary
in a large portion of this population in order to achieve appropriate glycemic control.
Objective: To evaluate glycemic control achieved with recombinant human insulin
NPH - Gansulin and compares it with human NPH insulin - Humulin N® in patients
with Type 2 Diabetes Mellitus. Subjects and methods: A prospective, double-blind,
randomized, parallel, single center with 37 individuals with type 2 diabetes using
insulin NPH insulin. For statistical analyzes were used: the multiple comparison test
of Tukey-Kramer test, Wilcoxon paired comparison test and Chi- Square. It was
regarded level of significance value lower than 5% (p<0.05). Results: Insulins NPH
and Humulin Gansulin showed similar reductions in HbA1c at the end of the study
compared to baseline. Initial HbA1c 7.91% in the Humulin group was reduced to
6.56% (p<0.001) at the end of the study whereas in the Gansulin the glycated
hemoglobin was reduced from 8.18% to 6.65% (p<0.001). At the end of the study
there was no significant difference between the glycated hemoglobin levels
(p=0.2410), fasting blood glucose (p=0.9257) and glucose at bedtime (p=0.3906)
between the two types of insulin. Regarding the number of hypoglycemic events,
there was no significant difference between the two insulins and no severe
hypoglycemic episodes were recorded. Conclusion: The NPH Gansulin (Insuneo
N®) presented glycemic control similar to that presented by human insulin Humulin
N® in patients with DM2. It was considered level of significance value less than 5%.
Descrição
Citação
RASSI, N. Estudo comparativo entre duas insulinas humanas recombinantes NPH no tratamento do diabetes mellitus tipo 2. 2014. 128 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2014