Estudo das manifestações da esclerose sistêmica no esôfago estômago e duodeno por meio de endoscopia digestiva alta
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2015-07-16
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Universidade Federal de Goiás
Resumo
Introduction: Systemic sclerosis is an autoimmune connective tissue
disease of unknown etiology characterized by fibrosis and inflammation. The
gastrointestinal tract is affected in 90% of patients and the esophagus is the
most affected organ. Objectives: Analyze the esophagus-gastroduodenal
changes, through endoscopy in patients with systemic sclerosis. Describe the
esophagus-gastroduodenal endoscopic alterations found. To verify the
association between esophagus-gastroduodenal endoscopic changes,
clinical forms of systemic sclerosis and autoantibodies. Methods: A
descriptive cross-sectional study that studied 20 patients older than 18 years
with systemic sclerosis diagnosis. Patients underwent endoscopy and
epidemiological data were collected from medical records. Endoscopic
findings were described and associated with data. Statistical analysis was
performed using the SPSS program for Windows, version 16.0. The Fisher
Exact test was used to compare variables. A significance level value of 5%
(p<0.05) was used. Results: The mean age of the patients was 45.65 years
(29-67 years). Eighteen patients were female and the mean disease duration
was 6.94 years. Sixteen patients (80%) had one or more esophageal
abnormalities, one being stricken with esophageal stenosis. Of the nineteen
patients who had gastric and duodenal evaluation performed, all had one or
more gastric involvement and five patients had duodenal abnormality. The
salivary stasis and esophageal hiatal hernia were the most frequent
esophageal abnormalities, followed by esophagitis. The mild enanthematous
gastritis in antrum was the most common gastric change followed by
moderate enanthematous pangastritis and enlarged cardia. The most
common duodenal change was the mild enanthematous bulboduodenite. Half
of the patients had diffuse systemic sclerosis and half had limited systemic
sclerosis. Fifteen patients were antinuclear factor positive. The association
between the data collected and endoscopic changes did not show statistical
significance, except for the association between salivary stasis and the
limited clinical form of systemic sclerosis. Conclusions: Patients with
systemic sclerosis have esophageal, gastric and duodenal endoscopic
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changes. Associations are not found between gastric and duodenal
endoscopic manifestations and clinical forms of the disease. Esophageal
salivary stasis is associated with limited clinical form of systemic sclerosis.
There is no association between the esophagus-gastroduodenal endoscopic
manifestations and the presence of autoantibodies
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Citação
XIMENES, R. O. Estudo das manifestações da esclerose sistêmica no esôfago estômago e duodeno por meio de endoscopia digestiva alta. 2015. 69 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.