Eficácia analgésica da cetamina administrada em infusão contínua em cadelas submetidas a mastectomia unilateral
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2015-04-29
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Universidade Federal de Goiás
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This study evaluated the analgesic effects of ketamine administered by three intravenous continuous infusionprotocols (IC) in bitches undergoing mastectomy. Twenty-five bitches were distributedrandomly in three groups: intraoperative continuous infusion group (CONTROL, n=8), receiving the IC only during the intraoperative period; 12-hour continuous infusion group (IC12, n=8), receiving the IC during the intraoperative period and for 12 hours after surgery; and 24-hour continuous infusion group (IC24, n=8), receiving the IC during the intraoperative period and for 24 hours after the surgery. Cardiorespiratory evaluations were performed during the perioperative period, and two researchers evaluated the postoperative analgesia by the interactive visual analog scale (VASi) and by the Short form of Glasgow composite pain scale (GCPS-SC), 10 minutes and 2, 4, 6, 8, 12, 18 and 24 hours after extubation. Owners evaluated their dogs using a questionnaire adapted from the "Helsinki Chronic Pain Index" on the 4th and 10th daysafter the surgical procedure. Pain scores and postoperative opioid requirements did not differ among groups. Rescue analgesia was administered to 7/8, 7/8 e 6/8 bitches in CONTROL, IC12 and IC24 groups, respectively. The main adverse effects observed were tachycardia, tachypnea, hypertension and excitement. According to the owners’ criteria, the animals of IC12 and IC24 groups had lower pain scores on the 4th and 10th days after the surgical procedure. We concluded that, although some mild adverse effects could occur, IC of ketamine is an effective and safe analgesic adjuvant in the early postoperative period. However, the main benefit of the prolonged Ketamine IC is probably related to the best quality of life andrecovery in the last postoperative period.
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SILVA, J. A. R. Eficácia analgésica da cetamina administrada em infusão contínua em cadelas submetidas a mastectomia unilateral. 2015. 55 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2015.