Expressão de proteínas de adesão (e-caderina e β - catenina) e proliferação celular (ki-67) no fronte de invasão tumoral de Carcinomas Espinocelular e Escamoso Basalóide
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2014-07-07
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Universidade Federal de Goiás
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Objective: Investigate, on a comparative basis, the expression of the adhesion molecules E-cadherin (E-cad), β-catenin (β-cat) and the proliferation index (Ki-67) at the invasive tumor front (ITF) in Squamous Cell Carcinoma (SCC) and basaloid squamous cell carcinoma (BSCC).
Material and Methods: Thirty-five SCC and 16 BSCC cases were evaluated by immunohistochemistry. Clinico-pathological data and survival data were evaluated and compared.
Results: There was a low expression of E-cad in the cytoplasmic membrane (p = 0.50) as well as in the nucleus (p = 0.31) for both SCC and BSCC. A high expression of E-cad was seen in the cytoplasm for the SCC group (80%) when compared to the BSCC group (25%) (p<0.01). The expression of β-cat in the cytoplasmic membrane (p = 0.28) and in the cytoplasm (p = 0.44) was low in both SCC and BSCC groups. Both types of carcinoma presented low expressions of β-cat in the nucleus (p = 0.03). The Ki-67 expression was low irrespective of tumor variant. The high expression of E-cad in the cytoplasm was associated with T3/T4 tumors (p = 0.04) in the SCC group and there was no significant association of E-cad, β-cat, Ki-67 with the other clinical variables. In terms of disease-free survival and overall survival, there were no significant differences between SCC and BSCC.
Conclusion: The E-cad-β-cat system was found to be dysregulated in both oral SCC and oral BSCC. The Ki-67 cell proliferation index was extremely low in the cases investigated and consequently had no prognostic value.
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PEREIRA, Carlos Henrique. Expressão de proteínas de adesão (e-caderina e β - catenina) e proliferação celular (ki-67) no fronte de invasão tumoral de Carcinomas Espinocelular e Escamoso Basalóide. 2014. 92 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2014.