Lesão tecidual e perfil de citocinas na neurocisticercose experimental
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2015-11-09
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Universidade Federal de Goiás
Resumo
The cysticercosis is endemic and is considered neglected by the World Health Organization. The neurocysticercosis (NCC) is the most common and severe form of cysticercosis, accounting for over 50,000 deaths annually. The use of experimental models in research, has been essential to the advancement of knowledge of various diseases, such as in understanding the pathophysiology, immune response and parasite host reactions. This study aimed to characterize the cellular immune response in situ and systemic, and the role of inflammatory cells in triggering changes in myelin standards. For this, we used an experimental model to evaluate the NCC intraventricular concentrations of cytokine in situ and systemically, by spleen cell culture, and changes in parenchymal patterns and periventricular desmielinizarão throughout the experimental period. No changes were detected in cytokine concentration at the infection site. Systemically, it is observed the presence of IL-10 initially and after 30 days of infection, there is a significant presence of all the cytokines analyzed as IL-4, IL-10, IL-17 and IFN-γ in the infected group. At the end of the infection, the Th2 profile was predominant. In evaluating pathological observed breaking the blood-brain barrier (BBB) allowing the initial influx of inflammatory cells in the two groups. At 30 days, there was a mixed inflammatory process, ventriculomegaly, foamy macrophages and periventricular desmielinizarão. At the end of the infection, predominance of mononuclear cells, ventriculomegaly, foamy macrophages and demyelination in the parenchyma mostly. In conclusion, the systemic immune response of BALB / c mice induced by cysticercus T. crassiceps, was characterized by a Th2-type immune profile and desmielinizarão parenchymal infection possibly at the end of the inflammatory process as well as the compressive effect on the parenchyma of the parasite brain.
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Neurocisticercose experimental , Resposta imune , Citocinas , Lesão tecidual , Desmielinizarão periventricular , Desmielinizarão parenquimal , Taenia crassiceps , Experimental neurocysticercosis tissue injury , Immune response , Demyelination periventricular , Parenchymal demyelination , Taenia crassiceps
Citação
MOURA, V. B. L. Lesão tecidual e perfil de citocinas na neurocisticercose experimental. 2015. 85 f. Tese (Doutorado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2015.