Banco de Cérebros do Brasil Central (BCBC): prevalência de demências e correlação clínico-patológica
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2016-01-29
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Universidade Federal de Goiás
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The diagnosis of dementia is made through autopsy. The histopathological and immunohistochemical technique makes it possible to differentiate the subtypes of dementia by pre-established macroscopic and microscopic criteria. Banks brain, although recent, provide biological material quality for multidisciplinary research in normal subjects and with dementia. Objectives: To correlate clinical findings with neuropathological cases with dementia from the Brains Bank of Central of Brazil (BBCB); establish morphological patterns in macroscopic focal dementias; determine the prevalence of diagnosis of other types of dementia. Materials and Methods: Brain Study from autopsies of patients with neurodegenerative diseases of dementia clinic of the HC-UFG (Ethics Committee of the Protocol on research 0692007). The brains were processed following dissection and measurement protocol. Appropriate external and macroscopic morphological descriptions and coronal and sagittal sections were performed. Results: 15 brains, 9 female patients were studied, aged 10 to 89 years. The types of dementias found in BCBC were 5 cases of frontotemporal dementia (FTD), 3 Alzheimer's disease (AD), 3 patients had primary progressive aphasia (PPA) and corticobasal degeneration (CBD), 1 Huntington's disease, 1 disease Creutzfeldt-Jakob 1, Rasmussen's encephalitis and 1 depressive pseudodementia (Cotard’s syndrome). Described frontal gyrus supernumerary in 3 cases of CBD and 2 cases of FTD. Discussion: Most cases presented morphological pattern of the respective type of dementia according to the literature, except PPA with CBD. In BCBC material only 20% of AD cases were 27% and frontotemporal lobar degeneration (FTLD). Conclusion: The higher prevalence of dementia in BCBC was the type FTLD. The frontotemporal focal atrophy was the most observed type of change. The cases with FTD showed classic morphological patterns, while the PPA CBD was different standard literature. The BCBC will enable studies in various research areas.
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DA SILVA, W. G. Banco de Cérebros do Brasil Central (BCBC): prevalência de demências e correlação clínico-patológica. 2016. 119 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.