Investigação molecular de vírus respiratórios em população pediátrica em Goiânia, Goiás
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Data
2016-04-08
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Universidade Federal de Goiás
Resumo
The acute respiratory infections (ARIs) are an important cause of morbidity
and mortality worldwide. Viruses have an important role in the etiology of the
respiratory infections. Children less than five years of age have about four to six ARIs
per year and this is a common cause of hospitalization, mainly in developing countries.
In Brazil, particularly in the West-Central region, studies that evaluated the circulation
of respiratory viruses in the pediatric population are scarce. Thus, this study aimed to
investigate the occurrence of respiratory viruses in the pediatric population, from
Goiânia-Goiás. Between May/2014 and May/2015, samples of nasal swabs were
collected from children from zero to six years of age presenting or not respiratory
symptoms, attended at the Materno Infantil hospital in Goiânia. For the molecular
screening, 16 viruses were investiged using three Multiplex Nested-PCR protocols. It
two hundred and fifty one samples were collected, of wich 90 (35,9%) were positive for
at least one respiratory agent, being rhinovirus (31%), respiratory syncytial virus
(27,4%) and parainfluenza virus (13,3%) the most prevalent. Children under two years
of age had greater overall positive, although not statistically significant. Similar
detection rate was observed among the groups symptomatic (37%) and asymptomatic
(34,5%). For the symptomatic group, children whose samples were collected during the
dry period (p<0,05) and those with up to two years of age were most affected (p<0,05).
In the asymptomatic group no statistical difference was observed. It was observed rate
of co-detection of 6,4% (16/251), mostly in samples of symptomatic patients (13/16)
(p<0,05). The evaluation of the temporal profile showed a higher detection rate during
the dry season, less rainfall, relative humidity and cooler temperatures. The results
reinforce the importance of respiratory viruses in children and contribute to further
understanding of the epidemiological and temporal factors associated with different
pathogens in our region. Thus, they open the way to new studies in the state of Goiás,
also providing information to assist in the construction of control measures and more
effective prevention of these infections.
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OLIVEIRA, A. C. R. Investigação molecular de vírus respiratórios em população pediátrica em Goiânia, Goiás. 2016. 118 f. Dissertação (mestrado em Biologia das Interações Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016.