Avaliação do efeito protetor do extrato bruto hidroalcoólico das folhas de Eugenia dysenterica DC. sobre a neurotoxicidade induzida pelo alumínio
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Data
2015-12-15
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Universidade Federal de Goiás
Resumo
incidence of neurodegenerative disease (ND) is increasing with the world
population aging. Among them, Alzheimer's disease (AD) is the most common of
dementia in the elderly population. The AD has been linked to oxidative stress
resulting in neurodegenerative disorders, such as the impairment of the antioxidant
and cholinergic systems. AChE inhibitors drugs are a treatment option used for AD.
However, until now, the drug treatment only temporary attenuates the AD symptoms
and new drug targets, as the medicinal plants, are necessary for a better treatment of
this disease. Eugenia dysenterica DC (Myrtaceae), popularly known as cagaita, is a
native plant from the Cerrado region of Brazil. It is used in the folk medicine to treat
diarrhea, jaundice and diabetes. Data from literature reported the presence of phenolic
compounds, such as flavonoids and tannins, in the leaves of E. dysenterica. Thus, the
aim of this study was to evaluate the neuroprotective effect of crude hydroalcoholic
extract of E. dysenterica leaves (HEED), using a model of neurotoxicity induced by
aluminium in mice and that causes similar cellular alterations of that observed in the
Alzheimer’s disease. The results showed the HEED increased the mice performance
in the passive avoidance test, showing the reversion of the cognitive damage
promoted by aluminium. In addition, the HEED reduced the neuronal lipid peroxidation
and restored the activity of superoxide dismutase (SOD), catalase (CAT) and
acetylcholinesterase (AChE) enzymes in mice brain. The histological analysis showed
the HEED decreased the incidence of neuronal death by necrosis. Taken together, the
results here obtained suggest that the antioxidant properties of HEED are the
responsible for its neuroprotective effect.
Descrição
Palavras-chave
Eugenia dysenterica DC. , Alumínio , Estresse oxidativo , Neurodegeneração , Doença de Alzheimer , Defesas antioxidantes , Defesas antioxidantes , Atividade anticolinesterásica , Aluminium , Oxidative stress , Neurodegeneration , Alzheimer's disease , Antioxidant defensesa , Anticholinesterase activity
Citação
PEIXOTO, L. F. Avaliação do efeito protetor do extrato bruto hidroalcoólico das folhas de Eugenia dysenterica DC. sobre a neurotoxicidade induzida pelo alumínio. 2015. 62 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2015.