Avaliacão da atividade anti-inflamatória do composto LQFM 147, um candidato a protótipo de farmaco
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2016-09-10
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Universidade Federal de Goiás
Resumo
Inflammation is a body protection process in response to tissue damage in order to
eliminate the offending agent and promote tissue repair. It is characterized by the
appearance of the classic signs such as pain, heat, redness and edema, which may occur
due to loss as a result of poor resolution of the inflammatory process. The use of antiinflammatory
drugs to control inflammation is widely used, but have many side effects,
making necessary the search for new drugs with fewer side effects and more effective.
The objective of this study was to evaluate the anti-inflammatory activity and / or
antinociceptive the LQFM 147 compound using acute tests of nociception and
inflammation, to characterize the mechanisms involved in such effects. For this study,
male mice were used, weighing between 30 and 35g. Treatment with LQFM 147 at doses
of 25, 50 and 100 mg / kg V.O. reduced the number of writhes in a dose-dependent in
16.79; 32.97 and 46.04%, respectively. In the formalin test, treatment with LQFM 147 at a
dose of 50 mg / kg V.O. It reduced the time of reactivity to pain testing only the
inflammatory phase 43.38%. The anti-inflammatory activity was confirmed, since the
treatment with LQFM 147 at a dose of 50 mg / kg V.O. reduced formation of paw edema
induced by carrageenan at all hours of the test, reduced migration of polymorphonuclear
leukocytes 40.82% in pleurisy test. Treatment with LQFM 147 was able to reduce the activity of myeloperoxidase in 31.54% and TNF-α levels of 65.51%. To obtain the results
the group treated with LQFM 147 was compared to the control group treated with vehicle
10 ml / kg v.o .. The data obtained demonstrate that LQFM 147 has anti-inflammatory and
antinociceptive activity involving the reduction of migration of polymorphonuclear
leukocytes and reduction in TNF-α levels.
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VASCONCELOS, P. A. Avaliação da atividade anti-inflamatória do composto LQFM 147, um candidato a protótipo de farmaco. 2016. 55 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2016.