Perfil genotípico e epidemiológico do carcinoma de células escamosas de laringe
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Data
2016-09-30
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Universidade Federal de Goiás
Resumo
The larynx has important functions in the body, such as speech and breath. A particular
pathology that affects this anatomical site will bring serious physiological problems, having a
significant impact on quality of life of the patient. The aim of this study was to evaluate the
clinical and epidemiological data, social-demographic and molecular patients diagnosed with
squamous cell carcinoma (SCC) of the larynx of the Registro de Câncer de Base Populacional of
Goiania (RCBP) of the Associação de Combate ao Câncer in Goiás (ACCG), analyzing the data
of 63 patients followed over a period of 6 years. This study was conducted at the Núcleo de
Pesquisa Replicon (PUC-GO) and LaGene (SES-GO), in order to evaluate the clinical and
epidemiological characteristics and molecular related to cancer of the larynx. This study found
no association between biometabolism genes of xenobiotics (CYP1A1, GSTM1 and GSTT1) and
susceptibility to SCC of the larynx. Additionally, the study of polymorphism in codon 72 of TP53
revealed that individuals Pro/Pro develop cancer of the larynx later than the Arg/Arg and
Arg/Pro patients. Comparing the case and control groups were observed an increased risk of
developing cancer of the larynx in the presence of the Arg/Pro genotype 2.7 times. The HPV
genome rate was 3% of analyzed samples (HPV16/45 and HPV11), all for Arg/Arg individuals.
The SCC larynx, in this study, occurred 3.5 times more men than women. Patients with tobacco
habits and chronic alcoholic and concomitant feature a significantly lower survival compared to
patients without such habits at an interval of six years. Additionally, the overall survival of the
larynx was approximately 66% in six years. This observation is directly related to smoking and
concomitant alcoholic habits, strengthening the participation of these factors in the initiation and
progression of SSC larynx. Additional changes in previously studied areas and the investigation
of other factors associated with laryngeal carcinomas can be important tools in estimating the
prognosis of tumor progression and hence improving the quality of life of patients.
Descrição
Palavras-chave
Polimorfismo , Câncer , Perfil , Laringe , Carcinoma de células escamosas , Genótipo , Molecular , Epidemiológico , Polymorphism , Cancer , Profile , Larynx , Squamous cell carcinoma , Genotypic , Molecular , Epidemiological
Citação
VASCONCELOS, P. M. F. Perfil genotípico e epidemiológico do carcinoma de células escamosas de laringe. 2016. 116 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.