Poliglecaprone na reparação intestinal e muscular de coelhos (Oryctolagus cuniculus)
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2017-03-13
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Universidade Federal de Goiás
Resumo
Currently chitosan, biomaterial has been widely used, and its derivative has
characteristics that can be absorbed by hydrolysis, are made by a monofilament and
induce a discrete tissue response. Despite presenting promising results, it is still little
known by the scientific environment and little commercially availability. The aim of this
study was to compare the influence of chitosan and polyglecaprone sutures on tissue
repair after cecorraphy and midline laparatomy closure rabbits (Oryctolagus cuniculus).
42 animals were allocated in two large groups, one of which was submitted to
cecorraphy and midline laparotomy closure with chitosan suture, and other one with
polyglecaprone. The postoperative complications were evaluated macroscopically and
the tissue reactions microscopically on the 5th, 15th and 25th postoperative days. They
were also, evaluated daily by the use of thermographic camera until the 15th day and,
when possible, on the 25th day. After thermographic evaluation, a statistical difference
was observed, obtaining p = 0.0003 between the Chitosan and Polyglecaprone groups.
Regarding the macroscopic evaluation, a statistical difference in the incidence of
complications between the groups was not observed. By the histological method, muscle
healing differed between the groups regarding only the granulation tissue intensity (p =
0.041) and fibrosis (p = 0.030) on the 15th postoperative day. The intestinal repair
evaluation differed only in the intensity of polymorphonuclear cells presence on the 15th
postoperative day (p = 0.041). In conclusion, chitosan and poliglecaprone sutures were
similarly effective in guaranteeing the healing of the cecum and rectus abdominis muscle
after cecorraphy and midline laparotomy closure after the 25-day postoperative period.
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ÁVILA FILHO, S. H. Poliglecaprone na reparação intestinal e muscular de coelhos (Oryctolagus cuniculus). 2017. 126 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2017.