Coinfecção pelo Papilomavírus humano e Chlamydia trachomatis em adolescentes e jovens em Goiás
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2016-03-30
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Universidade Federal de Goiás
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Infection with human papillomavirus (HPV) and the bacterium Chlamydia trachomatis (CT) are sexual transmission and may have synergistic action, especially in atypical induction in the cervix. One of the objectives of the study was to estimate the prevalence of co-infection by HPV and CT in adolescents and sexually active young women, and to assess the association with cytological abnormalities and factors related to sexual behavior, gynecological and obstetrical history. Another approach to coinfection in normal women and in women with cervical lesions was carried out in a systematic review (SR). The cross-sectional study included 276 adolescents and young people aged 15 to 24 years old, sexually active. A conventional smear was used for evaluation of cytological abnormalities. The detection of HPV DNA and CT was performed by polymerase chain reaction (PCR). The key words in the search for strategic for RS in PubMed, LILACS were HPV and Chlamydia trachomats, and the primary endpoint was the prevalence of coinfection HPV / CT and the inclusion criteria used diagnostic PCR in normal women and injuries the cervix. The cross-sectional study showed a prevalence of coinfection with HPV and CT was 5.8% (95% CI: 3.3 to 9.2); and 3.3% (95% CI: 1.5 to 6.1) for CT and one type of HPV and 2.5% (95% CI: 1.0 to 5.2) in combination with multiple infection viral types. The prevalence of CT infection was 9.1% (95% CI: 5.61 to 12.4). The prevalence of HPV infection was 47.1% (95% CI: 41.0 to 53.2). Thirty-six HPV types have been detected. The three most prevalent were HPV 16 (27,7%), followed by HPV 68 (8.5%) and HPV 52 (7.1%). The prevalence of cytologic abnormalities was 12.3% (95% CI: 8.68 to 16.79). The variables associated with coinfection HPV and CT and CT infection were the onset of sexual activity equal to or less than 16 years and the presence of cytological abnormalities. In RS, 291 articles were identified in PubMed and 26 in LILACS, totaling 317, of quais14 were eligible to compose the total sample review on the coinfection of HPV / CT. The prevalence of co-infection observed in cross-sectional studies ranged between 0.7% and 24.6%, and cohort studies. HPV infections and CT are very common among asymptomatic young. The results of the cross-sectional study reinforce the need for investment in screening programs for CT and ratify the preventive measures in particular the HPV vaccine in patients with young age preceding the onset of sexual activity. The RS shown that the prevalence of co-infection increases in the presence of cervical lesions, increasing the possible synergy of infections in the induction of cervical lesions.
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NONATO, D. R. Coinfecção pelo Papilomavírus humano e Chlamydia trachomatis em adolescentes e jovens em Goiás. 2016. 175 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2016.