Resposta inflamatória e resistência mecânica da parede abdominal de ratas após laparorrafia com fio de quitosana
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Data
2017-08-04
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Universidade Federal de Goiás
Resumo
Chitosan based materials are a class in development because they possess excellent
characteristics for use in the biomedical sciences. Regarding chitosan suture, few
studies have been performed and no studies have evaluated its response to systemic
inflammation and mechanical resistance. Therefore, the aim of this thesis is to
analyze the possible systemic inflammatory reactions in adult rats subjected to
laparorrhaphy with chitosan suture by means of the electrophoretic analysis of
polyacrylamide gel (SDS-PAGE) and its relation with the hematological findings and
biochemical. In addition, investigate the mechanical resistance of the abdominal wall,
the probable local inflammatory changes and the formation of collagen, through the
tensiometric and histopathological analyzes. To that end, 54 adult rats (Rattus
norvegicus) were divided into three groups, basel group (without surgery), chitosan
and polydioxanone (gold standard), evaluated at three, seven, 14 and 21 days after
laparorrhaphy. The result was that the chitosan and polydiaxonone wires have similar
behaviors in the systemic and local inflammatory response, although the
polydioxanone thread has a more intense response. In the evaluation of resistance,
they also presented similar results, and with polydioxanone, resistance was better on
the twenty-first day, with the conclusion that chitosan suture, despite the small
number of researches, is a promising thread. With this, perspectives are opened for
the use of chitosan suture in surgeries in veterinary medicine. However, as this is a
new product, other studies should be carried out, even in different areas, as well as
in other species / tissues and at different evaluation periods.
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Palavras-chave
Abdome , Eletroforese , Inflamação , Proteína , Sutura , Tensiometria , Abdômen , Electrophoresis , Inflamation , Protein , Suture , Tensiometry
Citação
GOMES, F. A. S. Resposta inflamatória e resistência mecânica da parede abdominal de ratas após laparorrafia com fio de quitosana. 2017. 68 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia,
2017.