Avaliação do perfil de parasitemia por hemocultura seriada em indivíduos infectados cronicamente pelo Trypanosoma cruzi
Nenhuma Miniatura disponível
Data
2010-03-30
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Over a hundred years have passed since the discovery of Chagas disease and it is still a
serious challenge to public health. Hemoculture has shown to be an important parasitological
method aiming the isolation of Trypanosoma cruzi as well as in doubtful diagnosis and in the
validation of the specific therapeutic efficacy. Its repetitive performance is another factor that
increases its sensitivity. The aim of this study was to evaluate the parasitaemia profile
through serial hemocultures from chronically T. cruzi infected individuals without previous
treatment. 50 individuals from both genders (60% males) which had venous blood collected
three fold with one month of minimum interval between the collections participated of this
study. The technique used was of Chiari et al. & Luz et al. with LIT medium resulting in seven
tubes per examination. Resulting in one performed hemoculture the sensitivity was of 32% in
the first, 32% in the second sample and 34% in the third. When adding up the cumulative
results of three samples the positivity increased to 58% (p=0,016). When we analyzed the
parasitaemia profile of the positive hemocultures, 42% were of low parasitaemia (none of the
three hemocultures were positive), 30% presented median parasitaemia (one hemoculture
positive from the three performed), and 28% presented high parasitaemia (two or more
positive hemocultures). When we related the parasitaemia level by hemoculture versus the
number of positive tubes by hemocultures we found a direct relation between the
parasitaemia and the number of positive tubes. Analyze the number of tubes positive blood
culture proves to be sufficient to define the profile of individuals with parasitemia middle and
high parasitemia, without the need for serial blood cultures. This can be expedited with the
release of results when the clinician intends to make specific treatment.
Descrição
Palavras-chave
Citação
NASCENTE, F. M. Avaliação do perfil de parasitemia por hemocultura seriada em indivíduos infectados cronicamente pelo Trypanosoma cruzi. 2010. 61 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2010.