Prevalência da infecção pelo vírus da hepatite C em hemodialisados no Estado do Tocantins
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2015-12-11
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Universidade Federal de Goiás
Resumo
The infection of hepatitis C virus (HCV) is a major public health problem that affects 130-150
million people, chronically, worldwide. HCV infection is highly prevalent among individuals
with chronic reanl disease (CKD). The objectives of this study were estimate the prevalence
of the infection with hepatitis C in hemodialysis patients of the State of Tocantins, analyze the
risk factors associated with HCV infection and characterize circulating genotypes in this
population. The study was conducted in 394 patients who were being treated in the
hemodialysis centers of the State of Tocantins, from October 2014 to February 2015. The
patients were interviewed, the questions were about sociodemographic characteristics and risk
factors for HCV infection and blood samples were collected. All samples were tested for
antibodies to HCV (anti-HCV) by means of enzyme-linked immunosorbent assay (ELISA).
The anti-HCV reagents samples were submitted to the detection of viral RNA by reverse
transcription polymerase chain reaction (RT_PCR) and genotyped by line probe assay method
(LiPA). The prevalence of HCV infection in hemodialysis patients was 2.8% (95% CI: 1.47 to
5.09). The viral RNA was detected in two of the eleven anti-HCV positive samples and
identified the genotype 1, subtype 1a in these samples. The treatment time of seropositive
patients was on average 105.19 months, and the negatives of 61.23 months. In univariate
analysis, prison records and history of sexually transmitted disease were significantly
associated with HCV infection. After the multivariate analysis, only the history of STDs
remained associated. The results of this study showed a significant reduction of HCV
infection in hemodialysis centers of the State of Tocantins, but the prevalence that was found
(2.8%) is almost double that seen in the general population of Brazil (1.38%). Therefore,
control strategies and prevention of hepatitis C in hemodialysis patients are extremely
important to prevent that infection in the sector of dialysis.
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CORDEIRO, V. M. Prevalência da infecção pelo vírus da hepatite C em hemodialisados no Estado do Tocantins. 2015. 80 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015.