Investigação do perfil soroepidemiológico da infecção pelo vírus da hepatite C em pacientes com diabetes mellitus tipo 2 em Goiânia- Goiás
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2015-04-10
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Universidade Federal de Goiás
Resumo
Hepatitis C (HCV) virus is one of the major cause of chronic liver disease worldwide
and 350,000 to 500,000 deaths occur each year related to the virus. Epidemiological
studies suggest that chronic HCV infection may have implications in the genesis of
some extra-hepatic diseases, among them diabetes mellitius type 2 (DM2). This study
aimed to describe the epidemiological profile of HCV infection in DM 2 patients. All
patients with DM2 that were followed up at the Hospital das Clinicas da Universidade
Federal de Goias and Unidades de Atenção Básica Saúde da Familia in Goiania-GO
were invited to take part in the research. 622 patients with DM 2 were recruited, of
whom 17 refused to participate. Therefore, the population was composed of 605
individuals, being the casuistry enough to the design of the study according to the
sample calculation. Individuals were interviewed and a blood sample was collected.
Sera were tested for the detection of anti - HCV by third-generation enzyme-linked
immunosorbent assay. Positive samples for this marker were submitted for detection of
viral RNA by Polymerase Chain Reaction post Reverse Transition (RT-PCR) and RNAHCV
positive samples were genotyped by Line Probe Essay method (LIPA). The
average age of the studied population was 62.1 years (SD = 11.3), female predominance
and 78.4% have up to 9 years of study. Nine samples were positive for anti-HCV,
resulting in a prevalence of 14.9% (95% CI: 0.73-2,9) for HCV infection in patients
with DM2. Viral RNA was detected in four anti-HCV positive specimens and genotypes
1 (2/4) and 3 (2/4) were identified. In the multivariate analysis, blood transfusion before
1994 and the use of illicit drugs were associated with HCV infection. Male remained
marginally associated (p = 0.06). Despite the global prevalence for HCV in patients
with DM 2 in Goiania-GO have been similar to the one found in the population in
general, more studies are needed to clarify the epidemiology of HCV infection in
individuals with DM 2 and provide information which can support prevention measures
and control of infection in this group of the population.
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SANTOS, L. S. M. Investigação do perfil soroepidemiológico da infecção pelo vírus da hepatite C em pacientes com diabetes mellitus tipo 2 em Goiânia- Goiás. 2015. 86 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015.