O extrato etanólico da casca de pequi reduz o dano cerebral induzido em ratas submetidas à dieta hipercalórica
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2017-03-17
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Universidade Federal de Goiás
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The aim was to determine the effect of ethanolic extract of pequi mesocarp on induced
brain damage and ERK1/2 and AMPKα active forms in rats subjected to a hypercaloric
diet. 48 rats were sorted into two groups of 24 according to the diet used, hypercaloric
or commercial, provided daily for 60 days. The animals were separated into two
subgroups of 12, treated or not with the extract, given daily for 30 days after diet start.
Quantification of triglycerides, induction of global cerebral ischemia followed by
reperfusion was performed. Later, euthanasia, brains harvest and visceral fat weighing
were performed. Histopathological evaluation of brain lesions, quantification of the
number of viable and non-viable cells in the cerebral cortex and hippocampus, and of
cells marked by the anti-pKR-ERK1/2 and p-AMPKα antibodies in the cerebral cortex
were performed. Hypertriglyceridemia and a significant increase in the amount of
visceral fat were observed in the group that received hypercaloric diet (p <0.05).
Histopathological evaluations showed that the group that received hypercaloric diet and
was treated with the extract had fewer brain lesions of ischemia and reperfusion. The
extract did not influence the number of viable and nonviable cells in the cerebral cortex
and hippocampus, but significantly reduced p-ERK1 / 2 and p-AMPKα cell labelling in
the hypercaloric diet group (p <0.05). In conclusion, ethanolic extract of pequi peel
reduces induced brain lesions in rats fed a hypercaloric diet and has a modulatory effect
on the expression of ERK1 / 2 and AMPKα in the cerebral cortex.
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MENDES, F. F. O extrato etanólico da casca de pequi reduz o dano cerebral induzido em ratas submetidas à dieta hipercalórica. 2017. 56 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia,
2017.