Biomaterial de quitosana, gelatina e óleo de pequi: obtenção, caracterização, avaliação da biocompatibilidade e da atividade antimicrobiana
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2018-03-01
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Universidade Federal de Goiás
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Recent researches in bioscience have been focusing in the development of biocompatible materials
to replace parts or function of living organisms. Moreover, versatility, low cost and minimally
tissue recctiveness are some of the major interest in biomaterial research. Several synthetic and
natural resources have been developed. Biometareial components’ features and particularities must
be thoroughly assessed to assure standardization and quality of the final product. The purpose of
this research was to develop and assess physicochemical and biological features of a chitosan,
pequi oil and gelatine based membrane for use in tissue regeneration. Components were mixed in a
proportion that kept homogeneity and integrity of the membrane. Membrane’s thermal analysis,
scanning electron microscopy, cytotoxicity and bactericidal/bacteriostatic and fungicidal/fungi-
static features were evaluated. It was observed that the membrane presented compatible
characteristics to be used in soft tissues and that there was no interaction between the components.
The presence of pequi oil did not interfere in the biomaterial cytotoxicity. Tests with
microorganisms revealed that there was no death or reduction of microorganism proliferation. It
was concluded that the mixture of the components allows to obtain a material in the membrane
format, however, new investigations are necessary to understand the mechanisms involved in the
presented cytotoxicity, as well as the behavior towards the microorganisms in the presence of
enzymes that degrade the material, simulating conditions of the animal organic fluid.
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BERTOLINO, Jéssica Fernanda. Biomaterial de quitosana, gelatina e óleo de pequi: obtenção, caracterização, avaliação da biocompatibilidade e da atividade antimicrobiana. 2018. 55 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2018.