Biomaterial de quitosana, gelatina e óleo de pequi: obtenção, caracterização, avaliação da biocompatibilidade e da atividade antimicrobiana

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2018-03-01

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Universidade Federal de Goiás

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Recent researches in bioscience have been focusing in the development of biocompatible materials to replace parts or function of living organisms. Moreover, versatility, low cost and minimally tissue recctiveness are some of the major interest in biomaterial research. Several synthetic and natural resources have been developed. Biometareial components’ features and particularities must be thoroughly assessed to assure standardization and quality of the final product. The purpose of this research was to develop and assess physicochemical and biological features of a chitosan, pequi oil and gelatine based membrane for use in tissue regeneration. Components were mixed in a proportion that kept homogeneity and integrity of the membrane. Membrane’s thermal analysis, scanning electron microscopy, cytotoxicity and bactericidal/bacteriostatic and fungicidal/fungi- static features were evaluated. It was observed that the membrane presented compatible characteristics to be used in soft tissues and that there was no interaction between the components. The presence of pequi oil did not interfere in the biomaterial cytotoxicity. Tests with microorganisms revealed that there was no death or reduction of microorganism proliferation. It was concluded that the mixture of the components allows to obtain a material in the membrane format, however, new investigations are necessary to understand the mechanisms involved in the presented cytotoxicity, as well as the behavior towards the microorganisms in the presence of enzymes that degrade the material, simulating conditions of the animal organic fluid.

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BERTOLINO, Jéssica Fernanda. Biomaterial de quitosana, gelatina e óleo de pequi: obtenção, caracterização, avaliação da biocompatibilidade e da atividade antimicrobiana. 2018. 55 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2018.