Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos
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2018-03-01
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Universidade Federal de Goiás
Resumo
Schizophrenia (EQZ) is a chronic mental illness that affects about 1% of the
world population and is characterized by behavioral domains such as positive
symptoms characterized by hallucinations and delusions and negative symptoms
that involve apathy, anhedonia and social blunting. The cause of EQZ remains
unknown, but it is known to be a disease whose etiology involves environmental
and genetic factors. Several studies seek to identify factors that clarify the etiology
of the disease. The agent that causes toxoplasmosis, Toxoplasma gondii, seems to be
related to the development and progression of the disease, evidenced by studies that
argue that T. gondii infection may be a triggering factor for psychosis in some
individuals, since the parasite has a certain tropism by the central nervous system.
Furthermore, studies have reported parasite infection as a factor related to
genotoxicity, including toxoplasma infection in an animal model. Based on the
foregoing, the present study aimed to evaluate the seropositivity to T. gondii (IgM
or IgG) and the avidity of IgG in a group of individuals diagnosed with EQZ in the
city of Goiânia and to evaluate the occurrence of genotoxicity in these, of
genotoxicity with exposure to xenobiotics such as tobacco, alcohol, especially
drugs, and / or T. gondii infection. Seropositivity was observed above 70% among
individuals diagnosed with EQZ in relation to the controls, with avidity above 50%,
indicating that individuals had contact with T. gondii at some time prior to the
survey. Despite the genotoxic damage found, there was no significant difference in
genotoxic damage among the infected individuals evaluated. The present study did
not demonstrate that T. gondii may be a contributing factor to the occurrence of
DNA damage, and the use of antipsychotic drugs, tobacco and alcohol, despite
being a risk factor for genotoxicity, did not demonstrate an influence significant
difference in the present study. However, it is necessary to carry out other analyzes
and investigate parameters such as the time of drug use and exposure to other
xenobiotics. In order to know better the life habits of individuals, it may help to
provide more information about this relationship between T. gondii and EQZ.
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Oliveira, N. G. M. Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos. 2018. 86 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2018.