Análise da genotoxicidade e da frequência de toxoplasmose em indivíduos diagnosticados com esquizofrenia
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2018-03-09
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Universidade Federal de Goiás
Resumo
Schizophrenia is a complex mental disorder in which the individual has difficulty
distinguishing between what is real and what is imaginary. It is a multifactorial disease in which
factors such as environment, genetic predisposition, toxoplasmosis and biochemical changes in the
brain are closely related to the severity of the disease, both positive and negative symptoms. The
present study aimed to evaluate the prevalence of toxoplasmosis and genotoxicity of Toxoplasma
gondii in individuals diagnosed with schizophrenia. The ELISA immunoenzymatic assay was used
to evaluate the seropositivity to T. gondii and the comet assay to detect genotoxic damage. In the
group, 69 individuals and 45 individuals who did not have schizophrenia or any mental disorder
were analyzed. A statistically significant difference (p <0.05) was observed when the mean age and
tobacco use frequency were analyzed, the individuals diagnosed with schizophrenia showed higher
seropositivity (p <0.01) when compared to the control group. Analyzing the mean ± SD (standard
deviation), they showed greater genotoxic damage in the case group in relation to the control
group. In addition, it was observed that the association between the genotoxic damage of the case
group with sex, IgG, disease, smoking and alcoholic beverages presented values of p> 0.05. Thus,
it can be concluded that there was no significant difference when comparing the genders to the
prevalence of toxoplasmosis in the individuals diagnosed with schizophrenia. In the case group it
was possible to verify greater genotoxic damage in the DNA than in the control group.
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PEDROSO, T. M. A. Análise da genotoxicidade e da frequência de toxoplasmose em indivíduos diagnosticados com esquizofrenia. 2018. 50 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2018.