Síntese e avaliação de novos candidatos a fotoprotetores absorvedores de radiações UVA e UVB, desenhados a partir de compostos análogos a produtos naturais
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2018-08-29
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Universidade Federal de Goiás
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It is known that sun exposure is one of the factors that contribute greatly to the appearance of skin cancer. Cancer cases have arisen annually on the planet and many of these cases have direct correlation with sun exposure. Knowing that both UVA and UVB radiation are harmful to health when the person is overexposed, the need arises for the use of devices to protect the skin and one of these ways and already recognized by the scientific community is through the prophylactic use of protectors solar power. Thus, this work proposes the synthesis, structural characterization, thermal stability verification, molar absorptivity calculation and in vitro UVB protection factor (PFUVB) calculated by the spectrophotometric method described by Mansur of new compounds derived from structures analogous to natural products. The structural planning was based on triazine derivatives (they are already commercially used with relative efficiency) and the use of chalcones, which are structures that besides having double bonds and conjugated aromatic structures that favor the absorption of the ultraviolet radiation, are studied compounds for various purposes and present in various plants, thus constituting a natural structure. In the planning, the choice of such structures was also due to the synthesis of compounds of high molar mass (above 900 daltons), contributing to safe structures, with low toxicity probability, low skin permeation and in compliance with the demands of the current legislation. The data obtained in the work reinforce the success of the same, where we had for the prototypes synthesized, molar absorptions superior to commercial filters. Establishing aresearch with the use of chalcones in safe and efficient sunscreens.
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LUZIN, R. M. Síntese e avaliação de novos candidatos a fotoprotetores absorvedores de radiações UVA e UVB, desenhados a partir de compostos análogos a produtos naturais. 2018. 102 f. Tese (Doutorado em Química) - Universidade Federal de Goiás, Goiânia, 2018.