Circunferência de cintura e ácido úrico em mulheres com e sem síndrome metabólica
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2019-04-18
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Universidade Federal de Goiás
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The metabolic syndrome is characterized by a set of risk factors for the development of
cardiovascular diseases, which are generally more concomitant than isolated, and are
related to obesity (particularly central). There is evidence of a relationship between
increased serum uric acid levels and altered metabolic syndrome components, as well as
the metabolic syndrome itself. Therefore, the objective proposed in the present thesis was
to analyze the alteration of this biomarker in the plasma and salivary fluid of women with
and without metabolic syndrome. For that, the uric acid levels alterations were evaluated
in 164 women with and without the presence of metabolic syndrome, aged 20 to 78 years,
attended by the Family Health Program (FHP) in the city of Santo Antônio de Goiás.
metabolic syndrome was identified according to the diagnostic criteria established by the
NCEP - ATP III, however, IDF (International Diabetes Federation) criteria were used to
compare the variables. The variables evaluated were abdominal circumference, fasting
blood glucose, HDL-cholesterol concentration, triglycerides and uric acid of the blood and
saliva, in addition to blood pressure measurement. Data were analyzed using the
statistical package SPSS (Statistical Package for Social Science), version 23. The level
of significance was set at 5% (p <0.05). The characterization of the sample was performed
by means of absolute and relative frequency for categorical variables and median, mean,
standard deviation and interquartile ranges for continuous variables. The Shapiro-Wilk
test was used to evaluate the normality of all dependent variables. In order to compare
the mean values between the CC categories, the Student t test (with Levene test for
equality of variance) or the Mann-Whitney U test were applied in the data with a normal
or non-normal distribution in both categories . The chi-square test was used to evaluate
the association between the classification of AUP and AUS with the exploratory variables.
Normality of the quantitative data was verified by applying the Kruskal-Wallis test. The
Mann-Whitney or Kruskal-Wallis test in the comparison of the mean values of the AUP
and AUS with the exploratory variables. Spearman's correlation was used to verify the
relationship between AUP and AUS values. Multiple linear regression was also performed
with the AUP and AUS values with the exploratory variables. Increased waist
circumference (≥ 80 cm, IDF or> 88 cm, NCEP-ATPIII) showed a significant correlation
with systolic blood pressure, diastolic blood pressure, glucose, HDL cholesterol, and
triglycerides. When participants were distributed by age, stronger correlations were
observed with the dependent variables mentioned above. In the bivariate linear regression
analysis with dichotomized health risk factors as dependent variable and increased waist
circumference as an independent variable, about 63.0% of the variability of the increase
in systolic blood pressure (≥ 130 mmHg) in the age group of 20 to 40 years was predicted
by increased waist circumference according to both criteria. There was a significant
association with age (p 0.01), systolic hypertension (p 0.05) and HDL cholesterol (p 0.03),
in relation to elevated levels of plasma uric acid (AUP). The same was not evidenced
when salivary uric acid (AUS) was used. It was observed that, even though there was no
significant difference, both mean values of AUP and AUS were higher in women with
confirmation of MS. When analyzing age as an exploratory variable, we found a significant
difference in relation to AUS and the different age groups (p 0.01), where the values
increased proportionally to the increase in age. When CC was analyzed, a significant
difference was identified between this component of MS and AUP (p 0.01). Based on the
study, it was possible to conclude that waist circumference above 80 cm in adult women
aged 20 to 40 years predicted strongly the variability in altered systolic blood pressure,
noting the importance of waist circumference measurement in monitoring and prevention
of cardiovascular and metabolic diseases in women in this age group. It is also concluded
that uric acid directly influences some of the components of MS, such as waist
circumference, systolic blood pressure and HDL cholesterol, as well as the metabolic
syndrome itself, although it did not find a significant difference when related to UA and
SM, it was observed that individuals with MS presented higher levels of uric acid.
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SILVA, G. R. A. Circunferência de cintura e ácido úrico em mulheres com e sem síndrome metabólica. 2019. 126 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2019.