Análise dos polimorfismos RS1800871 e RS1800872 do gene da interleucina 10 em indivíduos diagnosticados com esquizofrenia
Nenhuma Miniatura disponível
Data
2019-02-28
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Schizophrenia is an neurocognitive disorder that affects about 1% of the population.
Evidence shows that increases in the risks of the onset of schizophrenia (EQZ) and
other neuropsychiatric disorders are due to the imbalance of pro and antiinflammatory
agents associated with environmental and genetic components.
Cytokines are the major regulators of inflammatory immune reactions and brain
development and emerge as a common pathway for elucidation of the disease. This
study aims to evaluate whether there is an association between the rs1800871 and
rs1800872 polymorphisms of IL-10 gene and the susceptibility to the development of
schizophrenia by detection of polymorphisms (SNPs) by Sanger sequencing technique
in individuals giagnosed with EQZ in Goiânia, Goiás. Samples were collected from 156
individuals, 95 individuals diagnosed with EQZ (case group) and 61 healthy
individuals with no history of psychosis (control group). There isn’t association
between rs1800871 (p=0.97) and rs1800872 (p=0.83) SNPs and the susceptibility to
the development of EQZ. There was prevalence of smoking, alcohol use and chemical
dependency (p<0.001). The haplotype T/A had a higher frequency in the case group
(0,2).
Descrição
Palavras-chave
Citocinas , IL-10 , Anti-Infamatórias , SNP , Esquizofrenia , Cytokines , IL-10 , Anti-inflammatory , SNP , Schizophrenia
Citação
LOPES, A. T. C. Análise dos polimorfismos RS1800871 e RS1800872 do gene da interleucina 10 em indivíduos diagnosticados com esquizofrenia. 2019. 51 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2019.