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- Campus Samambaia, Campus Colemar Natal e Silva, Campus Aparecida de Goiânia.
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Análise de protocolos para o tratamento de sífilis congênita: uma revisão de escopo
(Universidade Federal de Goiás, 2024-06-14) Novais, Jordana Alves; Albuquerque, Juliana Silva; Garrido, Larissa Bernardes Araújo; Abe, Adriana Helena de Matos; Carvalho, Simone Resende de; Franco, Glaucimeire Marquez; Abe, Adriana Helena de Matos
Introduction: Congenital syphilis is an infectious disease caused by the bacterium Treponema pallidum with gestational transmission, which has a significant impact on the health of the fetus. Although prevention of this disease during pregnancy is safe and the treatment effective, its incidence has remained high in several countries, especially Brazil, which makes congenital syphilis a serious global public health problem that needs to be studied. Objective: To analyze the protocols for the treatment of congenital syphilis in Brazil and the United States in order to identify possible reasons for the increase in the incidence rate of this disease in different countries with different territorial areas, development rates and economies. Method: This is a scoping review based on a search of the PubMed database for the period 2013 to 2023. Results: One of the main factors responsible for the difference in congenital syphilis rates in each country is economic and territorial differences. In addition, the offer of screening for syphilis during pregnancy is not homogeneous throughout the territory of the countries analyzed and there are differences in the form of access for each social group within the same country. Conclusion: The protocols of the two countries analyzed are adequate and the biggest problem is adequate access to information and screening during prenatal care, treatment during pregnancy, for both the pregnant woman and her partner, and after childbirth.
Associação entre diabetes mellitus e capsulite adesiva: uma revisão sistemática e meta-análise
(Universidade Federal de Goiás, 2024-07-04) Piai, Ricardo Figueiredo Paro; Silva, Rômulo Freire Gomes; Oliveira, Thalles Pires de; Fernandes , Marcos Rassi; Costa, Paulo Sérgio Sucasas da; Naghettini, Alessandra Vitorino; Fernandes, Marcos Rassi
Adhesive Capsulitis (AC) is a progressive painful condition associated with a gradual reduction in the range of motion of the shoulder joint, being associated with factors such as Diabetes Mellitus (DM). DM is a metabolic disorder that can damage connective tissues, including the shoulder joint capsule, increasing the risk of developing CA. Brazil, with a high prevalence of DM, faces a significant number of CA cases. The results can provide important insights into the clinical management of these patients. This review aims to analyze the relationship between adhesive capsulitis and diabetes mellitus, considering sex, dyslipidemia and glycemic control as possible influencers. The present systematic review was carried out in the Scopus, Embase and PubMed databases until April 2024. Observational studies were included, without time limitations, that evaluated risk factors for CA. This study used the PECOT criteria and converted them into Medical Subject Headings (MeSH) terms to investigate the relationship between adhesive capsulitis and diabetes. The terms "frozen shoulder" OR "adhesive capsulitis", "shoulder", "diabetes" OR "diabetes mellitus" OR "diabetic", and "risk factors" OR "risk" were used, combined by the Boolean operator "AND" in their variations in the English language. Articles outside the scope of the topic, incomplete articles and articles in languages other than English were excluded from the study. This study presents three retrospective cohort studies, totaling 3,812,635 participants. Our study demonstrated that patients with DM2 are associated with a higher chance of developing CA compared to patients without DM2 (OR 2.17; 95% [CI] = 1.32 to 3.56; p = 0.002). Multivariate analysis indicated that individuals with DM2 were more likely to develop CA than those without DM2 (HR 1.46; 95% [CI] = 1.33 to 1.61; p < 0.00001). Dyslipidemia was also associated with an increased risk of AC in patients with T2DM (HR 1.37; 95% [CI] = 1.24 to 1.51; p < 0.00001). Furthermore, women had a higher risk of developing AC compared to men (HR 1.44; 95% [CI] = 1.23 to 1.69; p < 0.00001). A correlation was also observed between lack of glycemic control and the development of CA. In conclusion, this study highlights the strong association between T2DM, dyslipidemia, female sex and CA, emphasizing the importance of strict metabolic control and adequate management of dyslipidemia in patients with T2DM to prevent or minimize the risk of developing CA. Future prospective, randomized controlled studies are needed to confirm these findings and elucidate the mechanisms underlying this association.
Câncer de endométrio: o papel da terapia adjuvante
(Universidade Federal de Goiás, 2024-06-27) Anjos, Daniela dos Santos; Silva, Haila Cristina do Rêgo; Pereira, Isabella Victória Silva; Ramos, Marina Matos; Silva, Pedro Henrique Costa Matos da; Sousa, Juarez Antônio de; Ferreira, Sarah Hasimyan; Silva, Pedro Henrique Costa Matos da
Introduction: Endometrial cancer (EC) is one of the most common forms of gynecological cancer, significantly impacting women's health and an estimate of around 8.000 new cases in 2022 according to INCA (National Cancer Institute). This study investigates the current treatment approaches for women with endometrial cancer, with a particular attention to adjuvant therapy. Objective: The main objective is to understand the current landscape of adjuvant therapy in the management of endometrial neoplasia. Methodology: For the construction of the integrative literature review, a search was conducted in the SCIELO, PUBMED, and LILACS databases in January 2024, using the following descriptors: Endometrial Cancer, Treatment, Diagnosis, Management, Therapeutics, Endometrial Neoplasms, Câncer de Endométrio, Manejo, and Tratamento. Results: The search resulted in a total of 1.828 articles, of which 40 were selected based on the reading of titles and abstracts. From these, 18 texts were chosen for full reading, and finally, 9 were included. According to the evidence found, adjuvant therapy is recommended for patients at intermediate and high risk. In high-risk cases, combined chemotherapy can improve progression-free survival; however, the necessity must be evaluated individually. In advanced endometrial cancer, chemotherapy with Carboplatin and Paclitaxel is standard, but caution is needed due to toxicity, especially when associated with Doxorubicin. Regarding hormonal therapy, its effectiveness as an adjuvant is still unclear. Conclusion: Although the primary treatment for EC is surgical, adjuvant therapy plays a crucial role in patient prognosis, involving modalities such as chemotherapy, brachytherapy,
radiotherapy, and hormone therapy. Additionally, given the increasing incidence of endometrial cancer, there is an urgent need for more research to improve the management and adjuvant therapy, given the variations in observed prognoses.
Alimentação e hipertensão arterial sistêmica no Brasil: uma revisão integrativa
(Universidade Federal de Goiás, 2024-05-02) Pasqualetto, Alan Gabriel Natã; Brandão, Elymar Santana; Nascimento, Gabriel Melo Toledo; Barros, Fernando Passos Cupertino de; Azevedo, Monarko Nunes de; Pereira, Edsaura Maria
Systemic arterial hypertension is a disease with a prevalence of up to 1/3 of the Brazilian population and the 2020 guideline recommends changing diet as a form of control in all advances of the disease, with recommendation grade I and level of evidence A. The objective was to analyze in the literature which foods or diets were related to the control of this disease in the Brazilian population and discuss the principles of their effectiveness and the difficulties in their effective implementation. Search for articles published between January 2013 and March 2023 on Web of Science by MeSH descriptors, using the PICO strategy and classification by the GRADE system as selection criteria. 156 studies were obtained, 5 of which met the inclusion criteria, 3 of which were planned clinical trials, addressing the DASH diet and consumption of Brazil nuts, and 2 cohort studies on the risk of a diet rich in ultra-processed foods. Clinical trials obtained positive results on blood pressure levels and laboratory parameters, while groups with high consumption of ultra-processed foods had a relative risk and higher achievement. It was noted that dietary strategies sought to include common foods in Brazil, as a way of facilitating adherence for cultural reasons, however social disparities still remain limited.
Câncer de mama em homens: prevalência e suas principais características
(Universidade Federal de Goiás, 2024-06-29) Dias, Aylton Albernaz; Silva, Diego de Oliveira; Abreu Filho, Fernando Costa; Sousa, Juarez Antônio de; Amaral, Waldemar Naves do; Saidah, Tárik Kassem
Breast cancer is widely recognized as a major public health concern worldwide, predominantly affecting women. However, although it is relatively rare, breast cancer can also occur in men, accounting for a significant portion of cases diagnosed annually. Although less common, male breast cancer presents unique challenges in diagnosis, treatment, and clinical management, requiring a specific and personalized approach to ensure optimal patient outcomes. Understanding the prevalence and characteristics of breast cancer in men is critical to guide effective public health policies, prevention strategies, and clinical interventions. The general objective of this study is to discuss the prevalence and clinical, histopathological and therapeutic characteristics of breast cancer in men, in order to consolidate existing knowledge and identify gaps that can guide future research. The methodology of this work is the Literature Review. It is concluded that studies on breast cancer in men have provided a comprehensive view of this condition, from its prevalence to its main clinical characteristics and challenges associated with diagnosis and treatment.