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    Condições clínicas e determinantes sociais relacionados à mortalidade materna no brasil: uma revisão estruturada
    (Universidade Federal de Goiás, 2026-06-12) Santos, Laís Freire dos; Barros, Fernando Passos Cupertino de; Barros, Fernando Passos Cupertino de; Batista, Sandro Rogerio Rodrigues; Rassi Neto, Elias
    Introduction: maternal mortality is a serious public health problem, and most deaths are preventable. This integrative review synthesizes evidence on the clinical causes and social determinants associated with maternal mortality in Brazil. Objective: to synthesize evidence on clinical conditions and social determinants associated with maternal mortality in Brazil to inform public policy. Methods: integrative literature review (2014–2024) in PubMed/MEDLINE and Cochrane. Findings were organized into three axes: direct causes, indirect causes, and social/organizational determinants. Results and discussion: direct and indirect causes persist due to chronic failures in clinical management and risk screening. These failures are amplified by structural racism and socioeconomic vulnerability, which manifest as barriers to access and quality of care, summarized by the Three Delays Model (delays in deciding to seek care, reaching a facility, and receiving adequate treatment). Final considerations: maternal death is an indicator of inequity and structural failure. Effective intervention requires confronting institutional racism, strengthening Primary Health Care for risk screening and management, and ensuring a responsive care network - recognizing preventable maternal death as a violation of human rights.
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    Transtorno do espectro autista: diferenças clínicas entre meninos e meninas e seu impacto no diagnóstico
    (Universidade Federal de Goiás, 2026-06-18) Souza, Maria Gabriela Bezerra de; Lira, Júlia Amaral de; Trindade Júnior, Marcelo; Trindade Júnior, Marcelo; Afonso, Eliane Terezinha; Barros, Laiane Pereira
    Autism Spectrum Disorder (ASD) presents historical differences in prevalence between sexes, often related to diagnostic biases and the complexity of clinical manifestations. This study aimed to analyze the main clinical differences between boys and girls with ASD described in the contemporary literature. To achieve this, an Umbrella Review was conducted based on systematic reviews and meta-analyses published between 2015 and 2025, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The findings suggest that the classic 4:1 diagnostic ratio may be overestimated, with the actual incidence being closer to 3:1, especially due to the phenomenon of social camouflaging, in which girls mask autistic traits, contributing to underdiagnosis and delayed recognition. In addition, the female phenotype tends to present restricted interests that are more socially accepted, greater interpersonal motivation, and a higher frequency of internalizing symptoms, such as anxiety and depression, often related to the continuous effort of social adaptation. It was also observed that instruments considered the diagnostic “gold standard” have lower sensitivity in identifying female manifestations of the spectrum. Therefore, recognizing the particularities of ASD in girls is essential to promote greater diagnostic equity, reinforcing the need for more gender-sensitive assessment tools and further studies on the subject.
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    Mesa Saccharum: design efêmero comestível inspirado no microcosmo vegetal
    (Universidade Federal de Goiás, 2026-06-30) Azevêdo, Rodolfo Brito de; Badan, Rosane Costa; Badan, Rosane Costa; Hoelzel, Carlos Gustavo Martins; Silva, Ráisa Guerra e
    This study proposes the development of an edible ephemeral piece of furniture inspired by microscopic botanical structures. The research is based on the observation that edible furniture remains largely unexplored within the field of design, which has traditionally focused on creating durable and reproducible objects. The project translates natural structures observed in plant anatomy into a design artifact, considering that plant anatomy, visible only at the microscopic scale, offers a rich source of aesthetic inspiration by revealing a complex and unique universe—a true plant microcosm. Methodologically, the study is grounded in the principles of Food Design, biomimicry, and material experimentation, using edible ingredients as its primary material. This approach aims to create a sensory experience that encourages reflection on the lifespan of objects and, consequently, on consumption and sustainability. Ultimately, the research seeks to expand the boundaries of design beyond functionality, highlighting its potential to generate meaning and lasting memories even after the designed furniture has been consumed and has ceased to exist physically.
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    Tuberculose pulmonar e latente em pacientes com doença inflamatória intestinal na América Latina: revisão sistemática dos fatores associados
    (Universidade Federal de Goiás, 2026-06-11) Oliveira, Andressa Martins de; Silva, Geovana Ribeiro Cordeiro da; Couto, Sofia Souza; Lima, Livia Maria Lindoso; Lima, Livia Maria Lindoso; Rezende Filho, Joffre; Alvarenga, Antônio Rubens
    Tuberculosis (TB) remains a significant public health problem in Latin America, especially in immunocompromised individuals. Patients with Inflammatory Bowel Disease (IBD), including Crohn's disease and ulcerative colitis, frequently require immunosuppressive and immunobiological therapies, particularly anti-TNF agents, which can increase the risk of reactivation of latent Mycobacterium tuberculosis infection and the development of active tuberculosis. The aim of this study was to analyze the occurrence of active and latent pulmonary tuberculosis in IBD patients undergoing these therapies, as well as to identify the main factors associated with its development in Latin America. This is a systematic literature review conducted in the PubMed/MEDLINE, SciELO, and LILACS databases, including studies published between 2015 and 2025. Six studies were selected, encompassing cohorts, observational studies, case-control studies, and case reports. The results showed a consistent association between the use of anti-TNF agents, especially infliximab and adalimumab, and a higher risk of tuberculosis. Concomitant use of immunosuppressants, longer exposure time to biological therapies, male sex, occupational exposure, and residence in endemic regions were also identified as relevant risk factors. Furthermore, limitations in screening methods were observed, which may contribute to cases of active tuberculosis even after an initial negative screening. It is concluded that rigorous screening for latent tuberculosis and continuous monitoring during immunobiological treatment are fundamental to reducing the risk of infection in this population.
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    Avaliação cognitiva em pacientes portadores de doença renal estádio V em hemodiálise
    (Universidade Federal de Goiás, 2026-06-15) Belem, Bernardo Lemos Monteiro; Aleixo, Osmar Antônio Marçal; Pinto, Vítor Machado; Veloso, Mariana Pigozzi; Veloso, Mariana Pigozzi; Veloso, Valéria Soares Pigozzi; Barros, Lucas Simão de
    INTRODUCTION: Chronic kidney disease (CKD) constitutes a major public health problem and is associated with several systemic complications, including cognitive impairment. Patients with stage V CKD undergoing hemodialysis exhibit a high prevalence of cognitive decline, which can negatively impact treatment adherence, quality of life, and mortality rates. OBJECTIVE: To evaluate the cognitive status of patients with stage V chronic kidney disease undergoing hemodialysis using the Montreal Cognitive Assessment (MoCA) and to investigate associations between cognitive performance and clinical, demographic, and laboratory characteristics. METHODS: This was a cross-sectional, observational study conducted at a satellite hemodialysis unit in Goiânia-GO. A total of 132 patients aged 18 years or older, who had been on hemodialysis for more than six months, were evaluated. Cognitive assessment was performed using the MoCA, with scores below 26 points considered indicative of impairment. Clinical, demographic, and laboratory data were retrieved from electronic medical records. Statistical analyses included association tests, Spearman's correlation, and logistic regression, with a significance level set at 5%. RESULTS: Of the 132 patients evaluated, 81 (61.4%) presented with cognitive impairment. A significant association was found between poorer cognitive performance and advanced age (p=0.003), especially in individuals aged 70 years or older. Education level also showed a significant association (p<0.001), with a higher prevalence of cognitive alterations among patients with lower educational attainment. Regarding laboratory parameters, an association was observed between cognitive impairment and higher blood glucose levels (p=0.042) and platelet counts (p=0.048). Negative correlations were also identified between the total MoCA score and blood glucose (r=-0.17; p=0.050) and platelet count (r=-0.18; p=0.042). CONCLUSION: A high prevalence of cognitive impairment was observed in patients with stage V CKD undergoing hemodialysis. Advanced age and lower education levels were significantly associated with poorer cognitive performance, while blood glucose levels and platelet counts were related to a reduction in cognitive scores. These results reinforce the importance of systematic cognitive assessment in this population, contributing to the early identification of individuals at risk and to the planning of monitoring and intervention strategies.