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Item type: Item , Experimentação acessível: a design science na prototipagem de tecnologia assistiva para alunos com deficiência visual(2025) Benite, Claudio Roberto Machado; Rodovalho, Florisbelo Magalhães; França, Fernanda Araújo; Benite, Anna Maria CanavarroItem type: Item , Pedagogias críticas e a interseccionalidade na formação docente em ciências/química(2025) Faustino, Gustavo Augusto Assis; Alves, Camilla Ferreira; Nascimento, Keythy Ravena Batista; Santos, Itallo Junior Chaves dos; Vargas, Regina Nobre; Camargo, Marysson Jonas Rodrigues; Benite, Anna Maria CanavarroIn Brazil, the struggle of women for their rights, such as voting, freedom, autonomy, participation in the labor market, public life, and education, has been arduous and constant. Black women occupy a unique position in society, marked by multiple forms of oppression: gender, race, and class. Motivated by the desire to combat the disparity affecting women around the world, Black human rights activists have made significant advances in recent decades, ensuring greater attention to the issue of women's and gender rights abuses. With elements of participatory research, using Content Analysis (CA), our goal in this work was to investigate and describe the teacher training process in science, focusing on the development of a lesson conceived by course participants as part of the course evaluation around intersectionality and anti-racist education. Our results show that using Information and Communication Technologies (ICTs) with science teachers can be a way to diversify pedagogical strategies in educational practices. Additionally, the results highlighted the overlapping discriminations that shape Black women’s experiences, making it necessary to recognize the diversity and multiple dimensions of female identities. Finally, the analogies between intersectionality and their fields of study, resulting in words that express the complexity of the concept, encouraged students to reflect on the multiple dimensions present in the debate on this theme.Item type: Item , Miniaturized sample preparation strategies for the determination of N-nitrosamines in pharmaceutical products: A comprehensive review(2025-12) Batista Junior, Almir Custodio; Rocha, Yuri Arrates; Chaves, Andréa RodriguesN-Nitrosamines (NAs) are classified as potent mutagenic impurities, raising substantial concerns due to their presence in various consumer products, including pharmaceuticals products. The detection of NAs in valsartan-containing medicines in 2018 led regulatory agencies to establish strict guidelines for permissible levels in drug formulations. The standard-gold analytical techniques for NAs determination have been chromatographic techniques (liquid and gas chromatography) coupled with mass spectrometry system, which present higher sensibility and accuracy for target NAs. However, accurate determination of NAs in medicines remains challenging due to their trace-level concentrations and susceptibility to matrix effects, carryover, and contamination of the analytical instrumentation, emphasizing the need for robust sample preparation strategies. Traditional sample preparation methods, although effective, often involve high consumption of solvents, samples, and extraction phases, along with substantial waste generation. In response, miniaturized sample preparation techniques have emerged as sustainable alternatives, offering reduced solvent usage, minimal sample requirements, and lower energy consumption, all while maintaining analytical performance. These green approaches not only align with sustainable analytical practices but also enhance efficiency and environmental compliance in pharmaceutical analysis. This review provides a comprehensive overview of recent advancements in miniaturized sample preparation strategies for the determination of NAs in pharmaceutical products, highlighting their analytical merits and potential for regulatory adoption.Item type: Item , Educação para as relações étnico-raciais (ERER) na formação docente em química: abordando a temática corante azul(2025) Silva, Eliete Lucia; Camargo, Marysson Jonas Rodrigues; Benite, Anna Maria CanavarroThis study aimed to present and reflect upon an experience of incorporating the themes encompassed by Law 10.639/03—which mandates the teaching of African and Afro-Brazilian history and culture in basic education—into a teacher training program for Chemistry educators at a state university in the Central-West region of Brazil. More specifically, the focus was on the extraction of blue dye from Indigofera tinctoria, considered as a form of biotechnology originating from western Sudan (Mali). A pedagogical intervention (PI) was developed within a specific mandatory course in the program, targeting students in their seventh semester. The intervention was audio-recorded and subsequently transcribed for later analysis. The investigation was characterized as an action research project, and the data were examined through Conversation Analysis (CA). Our results revealed contradictions in the development of the PI related to discussions on racism; we identified epistemic shifts within the proposal, and we found it possible to discuss chemical concepts alongside topics related to African heritage and African history.Item type: Item , Metabolomic changes in rice (Oryza sativa L.) subjected to herbicide application through HPLC-HRMS and chemometrics approaches(2025) Batista Júnior, Almir Custódio; Roque, Jussara Valente; Lima, Nerilson Marques; Soares, Daniel de Almeida; Silva, Mellissa Ananias Soler da; Chaves, Andréa RodriguesThis study evaluated rice samples (Oryza sativa L.)─rice husk, husk and grain, polished grain, and unpolished grain─exposed to imazapyr, imazapic, and clomazone using high-performance liquid chromatography coupled to high-resolution mass spectrometry (HPLC-HRMS) and chemometric analysis. Partial least squares discriminant analysis (PLS-DA) was applied to HPLC-HRMS data, successfully distinguishing between herbicide-treated and control samples. Additionally, variable importance in projection (VIP) scores were then computed to identify key metabolites contributing to class differentiation, with higher scores indicating the most influential m/z values. These findings revealed metabolites affected by herbicide exposure and variations in the rice matrix. Furthermore, the most relevant m/z values were putatively annotated using spectral libraries, enabling the assessment of herbicide-induced metabolomic changes in rice. Herbicide treatment resulted in reduced free sugar levels across all rice matrices and led to a decrease in flavonoid content in the husk, indicating a potential suppressive effect on flavonoid accumulation. In addition, the herbicide treatment markedly disrupted the phenylpropanoid biosynthesis pathway. Overall, the combination of HPLC-HRMS analysis with multivariate approaches proved effective in detecting significant variations in the rice metabolome cultivated under herbicide application, paving the way for understanding the effects of herbicides in crop cultivation.