Estratégias de evasão de Staphylococcus aureus à imunidade inata

Abstract

Staphylococcus aureus is a microorganism that inhabits skin and mucous membranes of humans in a commensal form, but it can be associated with hospital and community acquired infections. Innate immunity is the first defense system of an organism, both animal and human. This microorganism is involved in the production of several virulence factors that aims to evasion innate immune system, as factors preventing the recognition and binding of pathogens by neutrophils, factors that provide protection against microbicidal substances of phagocytes. In addition, the microorganism is capable of secreting various cytotoxic molecules that have the ability to cause injury to the immune cells. Thus, on the relevance of the theme proposed to conduct a review of literature on the strategies of evasion of S. aureus to innate immunity in order to report the advances of science in this specific subject, the status of art, besides focusing on parallel, the cell evasion mechanisms.