Fisiopatologia do estresse oxidativo após isquemia e reperfusão cerebral e potencial neuroproteção do pequi (Caryocar Brasiliense)
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Data
2012-11
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Centro Científico Conhecer
Resumo
The ischemic cerebrovascular disease occur in 85-90% of cases and represent an important cause of mortality in the country, and are also responsible for considerable morbidity. So the investigation of the pathophysiology of the mechanisms involved in ischemic neuronal and endothelial injury is essential for designing new therapeutic approaches for the prevention and treatment of these diseases. Several mechanisms are involved in the pathophysiology of injury secondary to ischemia and reperfusion, the main one is the formation of reactive oxygen species. Under physiological conditions, their toxic effects can be prevented by some endogenous antioxidant enzymes, and also by other non-enzymatic antioxidants. However, when production becomes excessive, oxidative stress can have a deleterious effect on the structural integrity and function of biological tissues. Thus, the use of exogenous antioxidants, especially natural has increasingly been indicated for the prevention of lesions. So, this review aims to elucidate the pathophysiology of brain ischemia and reperfusion and the potential antioxidant activity of pequi cerrado as a future therapeutic method.
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Antioxidantes, Compostos fenólicos, Isquemia e reperfusão, Sistema nervoso central, Antioxidants, Phenolics compounds, Isquemia and reperfusion, Central nervous system
Citação
MIGUEL, Marina Pacheco; MENEZES, Liliana Borges de; ARAÚJO, Eugênio Gonçalves de. Fisiopatologia do estresse oxidativo após isquemia e reperfusão cerebral e potencial neuroproteção do pequi (Caryocar Brasiliense). Enciclopédia Biosfera, Goiânia, v. 8, n. 15, p. 1960-1976, nov. 2012.