Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association
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2009-02
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Purpose: To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB
(CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations.
Methods: Twenty three healthy female dogs randomly distributed in four groups named as GI (n=6), GII (n=6), GIII (n=6) and GIV
(n=5) were treated respectively with atropine and ketamine S(+) (0.04mg/kg; 10 mg/kg); ketamine S(+) (10 mg/kg); atropine, xylazine
and ketamine S(+) (0.04mg/kg; 1.1 mg/kg; 10 mg/kg) and xylazine and ketamine S(+) (1.1 mg/kg; 10 mg/kg). AST, CK and CK-MB
serum activity measurement before pre-medication (M0) and one, two, three, six, 12, 24, 36 hours after. Results: There was no
significant change in AST, CK e CK-MB serum activity among groups. However, CK serum activity in relation to moments within the
groups was increased in all groups over the time in spite of treatment, except GI.In relation to CK-MB activity, in the moments within the
group, it was observed an increase compared to baseline in all groups. Conclusion: Creatine kinase and creatine kinase fraction MB
isoenzyme showed changes in their mean values remained higher than baseline for a longer time in GIII and GIV.
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Isoenzymes, Atropine, Xylazine, Heart, Ischemia, Anesthetics dissociative, Dogs, Isoenzima, Atropina, Xilazina, Coração, Isquemia, Anestésicos dissociativos, Cães
Citação
FRANCO, Leandro Guimarães; FIORAVANTI, Maria Clorinda Soares; DAMASCENO, Adilson Donizeti; BORGES, Aline Cardoso; SOARES, Lorena Karine; SILVA, Luiz Antônio Franco da. Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association. Acta Cirúrgica Brasileira, São Paulo, v. 24, n. 1, p. 36-42, Jan./Feb. 2009.