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Tipo do documento: Artigo
Título: Effects of Brachiaria brizantha hay containing a steroidal saponin in lambs
Autor: Lima, Flávia Gontijo de
Ribeiro, Carolina Santos
Andrade, Diogo Francescantônio
Costa, Gustavo Lage
Pires, Hugo Cardoso Martins
Guimarães, Victor Yunes
Haraguchi, Mitsue
Fioravanti, Maria Clorinda Soares
Resumo: Several species of Brachiaria are important forages in tropical regions of Brazil and elsewhere worldwide. Some species of Brachiaria have been reported to cause hepatogenous photosensitization in ruminants. Initially, the disease was attributed to Pithomyces chartarum fungus, but recent studies suggest that the steroidal saponins present in the grasses have toxic principles responsible for the photosensitization. The objective of this study was to evaluate hepatic function and the performance of lambs fed with B. brizantha hay or sugar cane (Saccharum officinarum L.), using clinical examinations, laboratory tests, and macro and microscopic analysis of the liver. Twelve Saint Ines lambs were used. The animals were divided into two experimental groups: group hay (six lambs fed with B. brizantha hay, plus a concentrate feed) and group sugar cane (six lambs fed with roughage from sugar cane with added concentrate feed). The hay and sugar cane used to feed the lambs did not contain Pithomyces chartarum spores. The B. brizantha hay contained 0.86% protodioscin, and the animals received a daily protodioscin dose of 200 mg/kg BW. The clinical examination occurred every 7 days, the laboratory tests were done every 14 days, and the animals were weighed every 21 days. At the end of 93 days of feeding, the lambs were slaughtered, the macroscopic analysis of the organs was carried out, and the liver fragments were collected for histological analysis. The lambs were clinically healthy during the whole period, except at the beginning of the experiment when some animals had pneumonia. The only biochemistry alteration suggestive of hepatic damage was an increase (P < 0.05) of the GGT values in both groups. No animal fed with B. brizantha hay showed any macroscopic alterations in the liver. Histological analysis of the liver revealed preserved hepatocytes and the presence of light multifocal infiltration of mononuclear inflammatory cells in the hepatic parenchyma and also in the portal space, indicating mild cholangitis in both groups. Degeneration changes suggestive of hepatic steatosis were observed in four animals fed with sugar cane. Feeding lambs with B. brizantha hay promoted similar performance as feeding animals with sugar cane. We conclude that feeding B. brizantha hay containing the concentration of steroidal saponins used in this study to lambs does not cause toxicity.
Palavras-chave: Brachiaria brizantha
Gamma glutamyltransferase
Hepatogenous photosensitization
País: Estados unidos
Unidade acadêmica: Escola de Veterinária e Zootecnia - EVZ (RG)
Citação: LIMA, Flávia G.; RIBEIRO, Carolina S.; ANDRADE, Diogo F.; COSTA, Gustavo L.; PIRES, Hugo C. M.; GUIMARÃES, Victor Y.;HARAGUCHI, Mitsue; FIORAVANTI, Maria Clorinda S. Effects of Brachiaria brizantha hay containing a steroidal saponin in lambs. International Journal of Poisonous Plant Research, Washington, v. 2, n. 1, p. 20-26, 2012.
Tipo de acesso: Acesso Aberto
Data de publicação: 2012
Aparece nas coleções:EVZ - Artigos publicados em periódicos

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