Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15260
Tipo do documento: Artigo
Título: Genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of sulfonamide chalcone using the ames test and the mouse bone marrow micronucleus test
Autor: Silva, Carolina Ribeiro e
Borges, Flávio Fernandes Veloso
Bernardes, Aline
Noda Pérez, Caridad
Silva, Daniela de Melo e
Lee, Chen Chen
Abstract: Chalcones present several biological activities and sulfonamide chalcone derivatives have shown important biological applications, including antitumor activity. In this study, genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of the sulfonamide chalcone N-{4- [3-(4-nitrophenyl)prop-2-enoyl]phenyl} benzenesulfonamide (CPN) were assessed using the Salmonella typhimurium reverse mutation test (Ames test) and the mouse bone marrow micronucleus test. The results showed that CPN caused a small increase in the number of histidine revertant colonies in S. typhimurium strains TA98 and TA100, but not statistically significant (p > 0.05). The antimutagenicity test showed that CPN significantly decreased the number of His+ revertants in strain TA98 at all doses tested (p < 0.05), whereas in strain TA100 this occurred only at doses higher than 50 μg/plate (p < 0.05). The results of the micronucleus test indicated that CPN significantly increased the frequency of micronucleated polychromatic erythrocytes (MNPCE) at 24 h and 48 h, revealing a genotoxic effect of this compound. Also, a significant decrease in polychromatic/normochromatic erythrocyte ratio (PCE/NCE) was observed at the higher doses of CPN at 24 h and 48 h (p < 0.05), indicating its cytotoxic action. CPN co-administered with mitomycin C (MMC) significantly decreased the frequency of MNPCE at almost all doses tested at 24 h (p < 0.05), showing its antigenotoxic activity, and also presented a small decrease in MNPCE at 48 h (p > 0.05). Additionally, CPN co-administered with MMC significantly increased PCE/NCE ratio at all doses tested, demonstrating its anticytotoxic effect. In summary, CPN presented genotoxic, cytotoxic, antigenotoxic, and anticytotoxic properties.
País: Estados unidos
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: SILVA, Carolina Ribeiro e et al. Genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of sulfonamide chalcone using the ames test and the mouse bone marrow micronucleus test. Plos One, San Francisco, v. 10, e0137063, Sept. 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0137063
Identificador do documento: 10.1371/journal.pone.0137063
URI: http://repositorio.bc.ufg.br/handle/ri/15260
Data de publicação: Set-2015
Aparece nas coleções:IQ - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Carolina Ribeiro e Silva - 2015.pdf325,51 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons