Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15262
Tipo do documento: Artigo
Título: Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice
Autor: Carneiro, Cristiene Costa
Silva, Carolina Ribeiro e
Menezes, Antonio Carlos Severo
Noda Pérez, Caridad
Lee, Chen Chen
Abstract: Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as “bacupari”, “cascudo”, and “saputá”, is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test. Our results showed that none of the S. crassifolia fractions led to a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) (P > 0.05), suggesting the absence of genotoxicity. In the antigenotoxicity assessment, a significant decrease in the MNPCE frequency was observed in all fractions of this plant (P < 0.05), demonstrating its protective action against genotoxicity induced by mitomycin C (MMC), which was used as the positive control. Only the hexane fraction of S. crassifolia significantly decreased the poly- and normochromatic erythrocyte ratio (PCE/NCE) in all doses tested (P < 0.05), demonstrating its cytotoxic activity. In association with MMC, both ethyl acetate and hydroalcoholic fractions significantly increased the PCE/NCE ratio in almost all doses tested (P < 0.05), demonstrating the protective action of S. crassifolia against the cytotoxic effect of the positive control. In contrast, the hexane fraction presented a significant decrease in the PCE/NCE ratio in all treatments (P < 0.05), demonstrating an increase in this plant’s cytotoxicity in mouse bone marrow cells.
Palavras-chave: Salacia crassifolia
Stem bark fractions
Micronucleus test
Cytotoxicity
Antigenotoxicity
País: Brasil
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: CARNEIRO, C. C. Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice. Genetics and Molecular Research, Ribeirão Preto, v. 12, p. 2167-2177, July, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4238/2013.July.3.1
Identificador do documento: 10.4238/2013.July.3.1
URI: http://repositorio.bc.ufg.br/handle/ri/15262
Data de publicação: Jul-2013
Aparece nas coleções:IQ - Artigos publicados em periódicos

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