Ixorine, a new cyclopeptide alkaloid from the branches of Ixora brevifolia
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Data
2016
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Resumo
The isolation and structure determination of new cyclic peptide alkaloid ixorine, along with five
known constituents frangulanine, syringaresinol, cinnamtannin B-1, daucosterol and mannitol from
the branches of Ixora brevifolia are described. The cyclic peptide frangulanine is being described
for the first time in the Rubiaceae family. The structures were elucidated on their spectral data
basis, mainly one- (1H, 13C, DEPT) and two-dimensional (COSY, NOESY, HSQC and HMBC)
nuclear magnetic resonance (NMR) and by comparison with data from the literature. The mixture
of two cyclopeptide alkaloids showed weak activity against Leishmania amazonensis.
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Palavras-chave
Ixora brevifolia, Rubiaceae, Cyclopeptide alkaloids, Leishmania
Citação
MEDINA, Rebeca Previate et al. Ixorine, a new cyclopeptide alkaloid from the branches of Ixora brevifolia. Journal of the Brazilian Chemical Society, Campinas, v. 27, n. 4, p. 753-758, 2016.