Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15278
Tipo do documento: Artigo
Título: Inhibition of paracoccidioides lutzii pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives
Autor: Prado, Renata Silva do
Alves, Ricardo Justino
Oliveira, Cecília Maria Alves de
Kato, Lucília
Silva, Roosevelt Alves da
Quintino, Guilherme Oliveira
Cunha, Silvio do Desterro
Soares, Célia Maria de Almeida
Pereira, Maristela
Abstract: The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems. Adequate treatment of mycotic infections is difficult, since fungi are eukaryotic organisms with a structure and metabolism similar to those of eukaryotic hosts. In this way, specific fungus targets have become important to search of new antifungal compound. The role of the glyoxylate cycle and its enzymes in microbial virulence has been reported in many fungal pathogens, including Paracoccidioides spp. Here, we show the action of argentilactone and its semi-synthetic derivative reduced argentilactone on recombinant and native isocitrate lyase from Paracoccidioides lutzii Pb01 (PbICL) in the presence of different carbon sources, acetate and glucose. Additionally, argentilactone and its semi-synthetic derivative reduced argentilactone exhibited relevant inhibitory activity against P. lutzii Pb01 yeast cells and dose-dependently influenced the transition from the mycelium to yeast phase. The other oxygenated derivatives tested, epoxy argentilactone and diol argentilactone-, did not show inhibitory action on the fungus. The results were supported by in silico experiments.
País: Estados unidos
Unidade acadêmica: Instituto de Química - IQ (RG)
Citação: PRADO, Renata silva do et al. Inhibition of paracoccidioides lutzii pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives. Plos One, San Francisco, v. 9, n. 4, e94832, Apr. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0094832
Identificador do documento: 10.1371/journal.pone.0094832
URI: http://repositorio.bc.ufg.br/handle/ri/15278
Data de publicação: Abr-2014
Aparece nas coleções:IQ - Artigos publicados em periódicos

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