Atividade antiproliferativa de Sloanea garckeana K. Schum
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Data
2008
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Resumo
The crude methanol extract and hexane, ethyl acetate,
chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7,
NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the
ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of
12 μg/mL, 42 μg/mL, 53 μg/mL and 51 μg/mL, respectively. Through fractionation and isolation procedures compound (1) was
obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.
Descrição
Palavras-chave
Sloanea garkeana, Elaeocarpaceae, O-methyl ellagic acid-4’-O-α-L-rhamnoside
Citação
ROMERO, Adriano Lopes et al. Atividade antiproliferativa de Sloanea garckeana K. Schum. Química Nova, São Paulo, v. 31, n. 6, p. 1359-1361, 2008.